依达拉奉对心源性脑栓塞患者T淋巴细胞亚群及氧化应激水平的影响  

Effect of edaravone on T lymphocyte subsets and oxidative stress level in patients with cardiogenic cerebral embolism

作　　者：郭丽[1] 郑翔丽[1] 纪红[1] 严之红[1] 李镝[1] 

机构地区：[1]航天中心医院,北京100049

出　　处：《海南医学院学报》2016年第13期1369-1372,共4页Journal of Hainan Medical University

基　　金：航天中心医院科研课题项目(YN2013TS08)~~

摘　　要：目的：研究依达拉奉对心源性脑栓塞患者T淋巴细胞亚群及氧化应激水平的影响。方法：选取2013年6月～2015年6月我院接诊的100例心源性脑栓塞患者,分为对照组和观察组,对照组采取传统常规治疗方法,观察组采取依达拉奉治疗,观察两组治疗后辅助性T细胞4（CD4）、辅助性T细胞8（CD8）、谷胱甘肽过氧化物酶（GSH-Px）、活性氧簇（ROS）含量,观察不良反应情况及疗效。结果：两组治疗前CD4、CD8水平比较无统计学差异（P〉0.05）,治疗后CD4水平较治疗前明显上升,CD8水平较治疗前明显下降（P〈0.05）,观察组治疗后CD4、CD8水平改善明显优于对照组（P〈0.05）;两组治疗前GSH-Px、ROS比较无统计学差异（P〉0.05）,治疗后GSH-Px水平较治疗前明显升高（P〈0.05）,ROS水平较治疗前明显下降（P〈0.05）,观察组治疗后GSH-Px、ROS水平改善明显优于对照组（P〈0.05）;观察组不良反应发生率明显低于对照组（P〈0.05）,而治疗有效率明显高于对照组（P〈0.05）。结论：依达拉奉能有效纠正心源性脑栓塞患者T淋巴细胞亚群失衡,降低氧化应激水平,不良反应少,治疗作用显著。Objective：To explore the effect of edaravone on T lymphocyte subsets and oxidative stress level in patients with cardiogenic cerebral embolism.Methods：A total of 100 patients with cardiogenic cerebral embolism who were admitted in our hospital from June,2013 to June,2015 were included in the study and randomized into the observation group and the control group.The patients in the observation group were given edaravone,while the patients in the control group were given the conventional treatments.CD4,CD8,GSH-Px,and ROS levels,the occurrence of adverse reactions,and the clinical efficacy after treatment in the two groups were observed and compared.Results：The comparison of CD4 and CD8levels before treatment between the two groups was not statistically significant（P〉0.05）.After treatment,CD4 level was significantly elevated,while CD8 level was significantly reduced when compared with before treatment（P〈0.05）.The improvement of CD4 and CD8levels after treatment in the observation group was significantly superior to that in the control group（P〈0.05）.The comparison of GSH-Px and ROS levels before treatment between the two groups was not statistically significant（P〉0.05）.After treatment,GSH-Px level was significantly elevated,while ROS level was significantly reduced when compared with before treatment（P〈0.05）.The improvement of GSH-Px and ROS levels after treatment in the observation group was significantly superior to that in the control group（P〈0.05）.The occurrence rate of adverse reactions in the observation group was significantly lower than that in the control group,while the treatment effective rate was significantly higher than that in the control group（P〈0.05）.Conclusions：Edaravone in the treatment of cardiogenic cerebral embolism can effectively correct the imbalance of T lymphocyte subsets,and reduce the oxidative stress level,with less adverse reactions and significant therapeutic effect.

关 键 词：依达拉奉 心源性脑栓塞 T淋巴细胞亚群 氧化应激水平 

分 类 号：R743.3[医药卫生—神经病学与精神病学]