同步放化疗加巩固化疗治疗Ⅲ期不能手术老年非小细胞肺癌的疗效观察  

Observation of Efficacy of Concurrent Radiochemotherapy and Consolidation Chemotherapy for Inoperable Elderly Patients with Stage Ⅲ NSCLC

作　　者：黄亚妮[1] 龚志涛 

机构地区：[1]湖北省钟祥市人民医院,431900

出　　处：《实用癌症杂志》2016年第5期775-777,共3页The Practical Journal of Cancer

摘　　要：目的观察同步放化疗加巩固化疗与序贯放化疗治疗Ⅲ期不能手术老年非小细胞肺癌（non-small cell carcinoma,NSCLC）的临床疗效。方法临床纳入不能进行手术的老年NSCLC患者70例,根据治疗方案的不同分为研究组与对照组,研究组进行同步放化疗加巩固化疗,对照组进行序贯放化疗。观察：1治疗前后2组患者血清癌基因蛋白CD44v6、血管内皮生长因子（vascular endothelial growth factor,VEGF）水平;22组患者临床治疗有效率;3观察治疗期间2组患者不良反应发生情况。结果 1治疗前,2组患者血清CD44v6、VEGF水平差异无统计学意义（P〉0.05）;治疗后,研究组血清CD44v6、VEGF水平分别为（280.95±74.22）ng/L、（132.36±64.64）ng/L,对照组分别为（361.36±80.54）ng/L、（178.38±55.31）ng/L,差异有统计学意义（P〈0.05）;2研究组治疗有效率为74.29%,对照组治疗有效率为51.43%,差异有统计学意义（P〈0.05）;32组患者Ⅲ~Ⅳ级不良反应发生率比较差异无统计学意义（P〉0.05）。结论同步放化疗加巩固化疗治疗Ⅲ期不能手术老年NSCLC的疗效优于序贯放化疗,值得推广。Objective To observe the clinical efficacy of concurrent radiochemotherapy and consolidation chemotherapy and sequential chemoradiotherapy for inoperable elderly patients with stage Ⅲ NSCLC. Methods 70 inoperable elderly NSCLC patients were selected and divided into the research group and the control group according to different therapies. The research group adopted the concurrent radiochemotherapy followed by consolidation chemotherapy and control group adopted sequential chemoradiotherapy. 1 Before and after treatment,the levels of CD44v6 and VEGF of the 2 groups were observed; 2 The clinical effective rates of the 2 groups was observed; 3 The adverse effects of the 2 groups were observed. Results 1Before treatment,the levels of CD44v6 and VEGF of the 2 groups were not significantly different（ P〉0. 05）; after treatment,the levels of CD44v6 and VEGF of the research group were（ 280. 95 ± 74. 22） ng / L and（ 132. 36 ± 64. 64） ng / L while those of the control group were（ 361. 36 ± 80. 54） ng/L and（ 178. 38 ± 55. 31） ng/L（ P〈0. 05）; 2 The effective rate of the research group（ 74. 29%） was significantly higher than that of the control group（ 51. 43%）（ P〈0. 05）; 3 Grade Ⅲ ~ Ⅳ adverse effects of the 2 groups were not significantly different（ P〉0. 05）. Conclusion For inoperable elderly patients with stage Ⅲ NSCLC,the curative effect of concurrent radiochemotherapy and consolidation chemotherapy is better than that of sequential chemoradiotherapy. It is worthy of promotion.

关 键 词：同步放化疗加巩固化疗 序贯放化疗 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]