Ⅱ期结肠癌预后的影响因素分析  

Analysis of Prognostic Factors of Stage Ⅱ Colon Cancer

作　　者：杨智冉 刘彦龙[1] 杨艳梅[1] 唐洁冰[1] 陶冀[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,150000

出　　处：《实用癌症杂志》2016年第5期793-797,共5页The Practical Journal of Cancer

摘　　要：目的分析Ⅱ期结肠癌预后的影响因素。方法回顾性分析407例Ⅱ期结肠癌患者的临床病理资料。结果多因素回归分析表明,影响Ⅱ期结肠癌患者术后总生存期的独立危险因素是发病年龄〉60岁、术前CEA水平〉50ng/ml和肿瘤浸润深度T4。把没有任何一个危险因素的患者定义为低危组,有一个或更多危险因素的患者被定义为高危组。高危组与低危组中位生存时间比较有显著差异[分别为（79.04±1.51）个月和（96.65±3.14）个月,P=0.017],高危组风险比[hazard ratio（HR）]较低危组明显升高[3.201（95%CI为1.161~8.83）;P=0.025]。结论详细的病史采集、术前全面的检查以及准确的病理分期对于Ⅱ期结肠癌的预后分层具有重要的意义。Objective To investigate the prognostic factors of stage Ⅱ colon cancer. Methods Clinical pathological data of 407 cases of stageⅡcolon cancer were analyzed. Results Multiple factors analysis showed that the independent risk factors of stage Ⅱ colon cancer patients were age 〉60 years old,preoperative CEA level 〉50 ng / ml and T4 tumor invasion depth. The patients without risk factors were defined as low-risk group,the patients with 1 or more risk factors were defined as high-risk group. The median survival time of high-risk group and low-risk group had significant differences [（ 79. 04 ＋ 1. 51） months and（ 96. 65 ＋ 3. 14） months,P = 0. 017） ]. Hazard ratio（ HR） of high-risk group were significantly higher than that of low-risk group[3. 201（ 95% CI = 1. 161 - 8. 83）; P = 0. 025]. Conclusion Detailed history data,comprehensive preoperative examination and accurate pathological stage are of great importance for the prognostic stratification of stage Ⅱcolon cancer.

关 键 词：Ⅱ期结肠癌 临床病理因素 预后 

分 类 号：R735.35[医药卫生—肿瘤]