静-吸复合全麻对肝癌术中麻醉效果及患者肝功能的影响  

Effect of Static-Inhalation General Anesthesia in Liver Cancer Surgery and Its Influence on Liver Function

作　　者：范玲玲[1] 

机构地区：[1]内蒙古医科大学附属医院,010050

出　　处：《实用癌症杂志》2016年第5期860-862,共3页The Practical Journal of Cancer

摘　　要：目的观察静-吸复合全麻与硬膜外联合静脉麻醉对肝癌手术中麻醉效果以及肝功能的影响。方法临床纳入行肝叶切除术的肝癌患者70例,根据麻醉方式的不同分为研究组与对照组。研究组进行静-吸复合全麻,对照组进行硬膜外联合静脉麻醉。观察两组患术中情况(包括用药情况、术中出血量、术中输液量等)、术后情况(包括自主呼吸恢复时间、睁眼时间、拔管时间以及清醒时间)、肝功能情况等。结果研究组芬太尼、乌拉地尔、维库溴铵等使用剂量分别为(0.18±0.02)mg、(24.85±12.37)mg、(19.81±6.11)mg,对照组分别为(0.47±0.06)mg、(57.53±12.01)mg、(15.72±11.92)mg,差异均有显著性(P均<0.05);研究组自主呼吸恢复时间、睁眼时间、拔管时间、清醒时间分别为(424.85±81.37)s、(513.81±72.11)s、(634.59±141.15)s、(2.81±1.70)min,对照组分别为(577.23±152.01)s、(571.36±97.36)s、(757.46±132.25)s、(4.91±1.53)min,差异均有显著性(P均<0.05);研究组谷丙转氨酶(ALT)、谷草转氨酶(AST)水平分别为(112.85±61.40)U/L、(130.81±72.11)U/L,对照组分别为(243.23±152.01)U/L、(241.82±121.92)U/L,差异均无显著性(P均<0.05)。结论静-吸复合全麻对肝癌手术中患者的肝功能影响较小,且能够减少麻醉药物的应用,患者苏醒时间快,值得推广。Objective To study the effect of static-inhalation general anesthesia in liver cancer surgery and its influence on liver function. Methods 70 cases of liver cancer treated with lobe resection were divided into the research group and the control group based on different anesthesia methods. The research group were given static-inhalation general anesthesia while the control group were given epidural combined intravenous anesthesia. The intraoperative situation（ including medications,intraoperative blood loss,and intraoperative transfusion volume）,postoperative situation（ including spontaneous breathing recovery time,open time,extubation time,and waking hours）,liver function of patients in both groups were observed. Results The dosage of fentanyl,urapidil,vecuronium bromide of the research group were（ 0. 18 ± 0. 02） mg,（ 24. 85 ± 12. 37） mg,（ 19. 81 ± 6. 11） mg,and were（ 0. 47 ± 0. 06）,（ 57. 53 ± 12. 01） mg,（ 15. 72 ± 11. 92） mg in the control group. The difference was significant（ P〈0. 05）; The spontaneous breathing recovery time,open time,extubation time,and waking hours of the research group were（ 424. 85 ± 81. 37） s,（ 513. 81 ± 72. 11） s,（ 634. 59 ± 141. 15） s,and（ 2. 81 ± 1. 70） min,and were（ 577. 23 ± 152. 01） s,（ 571. 36 ± 97. 36） s,（ 757. 46 ± 132. 25） s,and（ 4. 91 ± 1. 53） min in the control group. The difference was significant（ P〈0. 05）; The ALT and AST of the research group were（ 112. 85 ± 61. 40） U / L and（ 130. 81 ± 72. 11） U / L,and were（ 243. 23 ±152. 01） U / L and（ 241. 82 ± 121. 92） U / L in the control group. The difference was significant（ P〈0. 05）. Conclusion Static-inhalation general anesthesia has little influence on the liver function of patients,with less narcotic drugs faster waking time,and it is worthy of promotion.

关 键 词：静-吸复合全麻 硬膜外联合静脉麻醉 肝叶切除术 肝癌 肝功能 麻醉效果 

分 类 号：R73-36[医药卫生—肿瘤]