光动力与声动力疗法杀伤肿瘤细胞的研究进展  

Research Advances in the Mechanisms of Photodynamic and Sonodynamic Therapy for Treating Tumor

作　　者：王月萍[1] 毕良佳[1] 

机构地区：[1]哈尔滨医科大学附属第四医院口腔科,哈尔滨150001

出　　处：《医学综述》2016年第9期1691-1693,共3页Medical Recapitulate

基　　金：高等学校博士学科点专项科研基金联合资助课题(20132307110018)

摘　　要：光动力疗法应用于人类肿瘤研究已有30年历史,随着一些光敏剂具有的声敏性被发现,声动力疗法便受到相关领域学者的关注。通过在声光领域对光动力疗法和声动力疗法杀伤肿瘤细胞机制的研究,发现两者可通过各自独特方式产生相似的活性氧类物质,继而启动相关凋亡通路来杀伤肿瘤细胞;同时,光动力疗法的免疫细胞趋化作用以及声动力疗法的超声热效应也分别展现了两者杀伤肿瘤细胞的独特作用方式。Over 30 years ago, photodynamic therapy was applied for the study of human tumor, and with the discovery of some photosensitizer having ultrasonic sensitivity, the sonodynamic therapy has drawn con- cerns from some scholars in related fields. Through investigating the mechanisms of killing tumor cells by photodynamic and sonodynamic therapy in respective areas, experts discovered that they could produce similar reactive oxygen species in their own way, and then kill tumor cells by activating the related apoptosis path- way. And the immune cells＇ chemotaxis effect of photodynamic therapy and the ultrasonic heat effect of sono- dynamic therapy have demonstrated their unique way of killing tumor ceils respectively.

关 键 词：光动力疗法 声动力疗法 肿瘤细胞 凋亡机制 

分 类 号：R73[医药卫生—肿瘤]