幽门螺杆菌感染与结肠腺瘤性息肉的相关性研究  

Association of Colonic Adenomatous Polyps and Helicobacter Pylori Infection:A Case-control Study

作　　者：唐斌[1] 张俊[1] 唐友攀 李月平[1] 雷丛珊 蒋波[1] 舒欧 

机构地区：[1]中江县人民医院,四川中江618100

出　　处：《中国循证医学杂志》2016年第5期513-516,共4页Chinese Journal of Evidence-based Medicine

摘　　要：目的探讨幽门螺杆菌(Hp)感染与结肠腺瘤性息肉发病风险的相关性。方法采用病例-对照研究设计,收集2014年2月至2015年9月在中江县人民医院确诊的结肠腺瘤性息肉患者的临床资料,并随机抽取该院同期结肠镜下未见异常者作为对照组,比较两组Hp阳性率的差异。进一步将结肠腺瘤性息肉患者按年龄、性别、居住环境、病变部位、蒂部分型、病理分型与息肉数目划分亚组,比较各亚组间Hp阳性率是否存在差异。采用SPSS 17.0软件进行统计分析。结果共纳入219例患者,其中病例组119例,对照组100例。病例组Hp阳性率为69.7%(83/119),对照组为52.0%(52/100),两组差异有统计学意义(χ2=7.239,P=0.007);结肠腺瘤性息肉患者各亚组间Hp阳性率差异均无统计学意义(P均>0.05)。结论 Hp感染可能会增加结肠腺瘤性息肉发生的风险。Objective To investigate the relation between colonic adenomatous polyps and Helicobacter pylori infection. Methods A case-control study was conducted to collect clinical data of patients with colonic adenomatous polyps in People＇s Hospital of Zhongjiang County from February 2014 to September 2015. Patients with healthy colon of the corresponding period of the hospital were collected as a control group. The difference of positive rate of Hp infection was compared between the colonic adenomatous polyps group and the control group. According to the age, gender, living condition, location, type of pedicle, pathological type and number, the colonic adenomatous polyps group was divided into subgroups and the differences of positive rate of Hp infection were compared among the subgroups. Results A total of 219 patients involving 119 cases and 100 controls were included. The positive rate of lip infection in the colonic adenomatous polyps group was significantly higher than that in the control group （69.7% vs. 52.0%） with a significant difference （X2=7.239, P=0.007）. Among 119 patients with colonic adenomatous polyps, no statistical differences were found in the positive rate of Hp infection among subgroups of different age, gender, living condition, location, type of pedicle, pathological type and number （all P values 〉0.05）. Conclusions Hp infection may increase the risk of developing colonic adenomatous polyps.

关 键 词：幽门螺杆菌 结肠 腺瘤性息肉 病例-对照研究 

分 类 号：R574.62[医药卫生—消化系统]