CXCL16基因rs2277680位点多态性与动脉粥样硬化性急性脑梗死的关系  

Association between chemokine CXC ligand 16 gene rs2277680 polymorphisms and atherosclerotic acute cerebral infarction

作　　者：陈云[1] 周元林[1] 朱敏[2] 蒋辉华[1] 朱峰[1] 王恩[1] 柯绍发[1] 韩文胜[3] 

机构地区：[1]温州医科大学附属台州医院神经内科,台州317000 [2]温州医科大学附属台州医院中心实验室,台州317000 [3]温州医科大学附属台州医院B超室,台州317000

出　　处：《中华神经医学杂志》2016年第5期467-471,共5页Chinese Journal of Neuromedicine

基　　金：浙江省医药卫生科研项目（2013KYB289）

摘　　要：目的探讨汉族人群血清趋化因子CXC配体16（CXCL16）基因rs2277680位点多态性与动脉粥样硬化性急性脑梗死的关系。方法选择台州医院神经内科自2013年9月至2015年3月收治的420例动脉粥样硬化性急性脑梗死患者（脑梗死组）和同期268例健康体检者（对照组）为研究对象，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法分析CXCL16基因rs2277680位点多态性并比较组间差异。结果rs2277680位点的AA＋GA基因型频率和A等位基因频率在脑梗死组和对照组间（87.9% vs 82.1%；69.5% vs 63.1%）差异均有统计学意义（P〈0.05）。多因素Logistic回归分析示AA＋GA基因型是动脉粥样硬化性急性脑梗死的独立危险因素（OR= 2.050，P=0.043，95%CI：1.021-4.113）。结论CXCL16基因rs2277680位点AA＋GA基因型与动脉粥样硬化性急性脑梗死的发病密切相关；A等位基因是动脉粥样硬化性急性脑梗死的遗传易感基因。Objective To investigate the association between chemokine CXC ligand 16 （CXCL16） gene rs2277680 polymorphism and atherosclerotic acute cerebral infarction （ACI） in Chinese Hart population. Methods Four hundred and twenty patients with acute ACI, admitted to our hospital from September 2013 to March 2015, and 268 healthy controls were included in the study. And polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was used to detect the rs2277680 polymorphisms in the CXCL16 gene. Results The distribution ofrs2277680 between the two groups was significantly different at both genotypic level （AA＋GA vs. GG=87.9% vs. 82.1%, χ^2=- 4.418, P=0.036） and allelic level （A vs. G=69.5% vs. 63.1%, χ^2=6.184, P=0.013）. The AA＋GA genotype was an independent risk factor for ACI （OR=2.050, P=0.043, 95%CI： 1.021-4.113）. Conclusion The rs2277680 polymorphism of CXCL16 gene is associated with atherosclerotic cerebral infarction in Chinese Han population; the A allele might be a genetic susceptibility gene which leads to ACI.

关 键 词：CXC配体16 动脉粥样硬化 脑梗死 多态现象 

分 类 号：R743.3[医药卫生—神经病学与精神病学]