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作 者:贺春钰[1] 司马义力.买买提尼牙孜 韩有溪 木妮热.木沙江
机构地区:[1]新疆医科大学附属肿瘤医院乳腺放疗科,乌鲁木齐830011
出 处:《中华实用诊断与治疗杂志》2016年第5期488-489,共2页Journal of Chinese Practical Diagnosis and Therapy
基 金:新疆医科大学科研创新基金项目(XJC201397)
摘 要:目的比较双侧乳腺癌患者改良根治术后双侧胸壁同时和异时放疗的2种调强放疗方案,探讨符合临床要求的最佳治疗方法。方法 10例接受改良根治术的双侧乳腺癌患者,分别制定双侧整体化照射(A方案)及分次先后照射(B方案)的逆向调强计划,根据剂量-体积直方图比较2种计划的优劣。结果 A方案靶区均匀指数(homogeneity index,HI)(1.42±0.02)、双肺V_(30)[(6.25±0.65)%]、V_(40)[(1.44±0.64)%]和心脏V_(20)[(47.90±15.93)%]、V_(30)[(11.60±7.20)%]、加速器总跳数(889.40±121.50)均低于B方案[HI为(1.74±0.04),双肺V_(30)为(6.82±0.75)%、V_(40)为(1.97±0.66)%,心脏V_(20)为(50.82±17.88)%、V_(30)为(13.86±6.80)%,加速器总跳数为(1 014.50±235.20),差异均有统计学意义(P<0.05)。结论剂量学上双侧同时放疗的逆向调强计划用于治疗双侧乳腺癌可行。Objective To explore the optimal treatment method by comparing simultaneous with asynchronously inverse intensity-modulation radiotherapy (IMRT) on the bilateral chest wall for primary synchronous bilateral breast cancer (PSBBC) after modified radical mastectomy. Methods Ten PSBBC patients after modified radical mastectomy received left and right chest walls simultaneous inverse IMRT (plan A) and left and right chest walls asynchronously inverse IMRT (plan B), which were compared by dose volume histograms. Results The homogeneity index (HI) (1. 42±0.02), lung V30 ((6.25±0.65)%), lung V40 ((1.44±0.64)%) and heart V20 ((47. 90±15. 93)%), heart V30 ((11.60±7.20)%), and monitor unit (889.40±121.50) in plan A were significantly lower than those in plan B (HI: 1.74±0.04, lung V30 : (6.82±0.75)%, lung V40 : (1.97±0.66)0/oo, heart V20 : (50.82±5. 17.88)%, heart V30 : (13.86±6.80)%, monitor unit: (1 014.50±235. 20) (P〈0.05). Conclusion Simultaneous inverse IMRT is dosimetrically feasible for PSBBC.
关 键 词:同时性原发性双侧乳腺癌 逆向调强放疗 剂量学
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