度洛西汀治疗帕金森病患者疼痛的疗效及安全性评价  

Efficacy and safety analysis of duloxetine on the pain of Parkinson's disease

作　　者：贺晓琴[1] 张洪[1] 黄文琴[1] 

机构地区：[1]四川眉山市中医医院神经内科,眉山620010

出　　处：《中国实用神经疾病杂志》2016年第5期24-25,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的分析度洛西汀治疗帕金森病疼痛的疗效和安全性。方法 30例帕金森病患者随机分为对照组和观察组,对照组采用美多巴治疗,0.5片/次,3次/d。以后每周的日服量增加1/2片;观察组服用度洛西汀60mg/d,顿服治疗12周。后对2组患者的治疗效果和用药的不良反应进行比较和分析。结果观察组患者的疼痛治疗效果优于对照组,观察组仅出现1例不良反应,对照组出现5例,差异具有统计学意义(P<0.05)。结论帕金森病患者采用度洛西汀治疗疼痛的疗效较美多巴效果好,用药不良反应较少,建议临床使用。Objective To analyze the effect and safety of duloxetine on the pain of Parkinson＇s disease. Methods Thirty cases with Parkinson＇s disease were randomly divided into the control group and the observation group. Patients in the control group took 1/2 chip of madopar each time, three times daily. After that the daily dosage was increased by 1/2 chip each week. Patients in observation group received 60rag duloxetine daily for 12 weeks. Then the clinical efficacy and adverse effects of two groups were comparatively analyzed. Results The clinical efficacy of observation group on the pain was better than that of con- trol group. Only one case in observation group and 5 cases in control group concomitant with adverse events showed statistical difference （P〈0.05）. Conclusion The application of duloxetine may exert an effect on the pain with better safety in Parkin- sonrs disease patients more favorable than madopar, which should be recommended in clinical promotion.

关 键 词：度洛西汀 帕金森病 不良反应 

分 类 号：R742.5[医药卫生—神经病学与精神病学]