偏头痛患者伴发心脏卵圆孔未闭脑血管反应性研究  

Study of cerebrovascular reactivity in migraine patients concomitant with patent foramen ovale

作　　者：孟凤珠 罗国刚[2] 刘蕊[2] 贾蕊[2] 卫萌[2] 周文婷[2] 

机构地区：[1]西安市第一医院老年病科神经内科病区,西安710002 [2]西安交通大学第一附属医院神经内科,西安710061

出　　处：《中国实用神经疾病杂志》2016年第6期1-2,共2页Chinese Journal of Practical Nervous Diseases

基　　金：国家"十二五"科技支撑计划项目(2014BAI04B05)

摘　　要：目的探讨心脏卵圆孔未闭(patent foramen ovale,PFO)与偏头痛的相关性,以及偏头痛伴发PFO患者的脑血管反应性差异。方法利用经颅多普勒超声声学造影(contrast transcranial Doppler,cTCD)及经颅多普勒超声(transcranial Doppler,TCD)屏气实验检查,对照分析西安交通大学第一附属医院神经内科2013-03-2013-10 62例偏头痛患者与43例正常志愿者,伴发PFO结果和脑血管反应性。结果偏头痛组PFO阳性率明显高于正常对照组(51.61%vs 27.91%,P=0.015),PFO阳性的偏头痛患者头痛侧大脑中动脉(middle cerebral artery,MCA)屏气指数(breath holding index,BHI)值明显低于PFO阴性患者(0.82±0.58vs 1.34±0.72,P=0.013)。结果偏头痛与PFO共患率高,偏头痛伴发PFO患者头痛侧脑血管反应性降低。Objective To explore the relationship between patent foramen ovale（PFO） and migraine, and to study the difference in the cerebrovascular reactivity in migraine patients concomitant with PFO. Methods In order to analyze the differ- ence in the eerebrovascular reactivity between PFO cases and non-PFO cases, the contrast transeranial Doppler （cTCD） and transcranial Doppler（TCD） were used to comparatively detect 62 migraine cases and 43 healthy volunteers from March 2013 to October 2013 in the First Affiliated Hospital of Xi ＂an Jiaotong University. Results The positive rate of PFO in migraine group was significantly higher than that in control group （51.61% vs 27.91%, P = 0. 015 ）. Additionally, PFO- positive patients showed higher breath holding index（BHI） of the middle cerebral artery（MCA） in the migraine headache side than PFO-nega- tive patients（0.82±0.58 vs 1.34±0.72, P=0. 013）. Conclusion There is a close relationship between migraine and PFO, and patients have a high co-morbidity rate. The cerebrovascular reactivity in migraine patients with PFO may be decreased in the headache side.

关 键 词：偏头痛 PFO TCD 屏气实验 脑血管反应性 

分 类 号：R747.2[医药卫生—神经病学与精神病学]