急性脑梗死患者血白细胞计数血清C反应蛋白水平的改变及意义  

Changes of peripheral blood leucocyte count and level of serum C-reactive protein in patients with acute cerebral infarction and their Significances

作　　者：原相丽[1] 李常红[2] 周正宏[2] 贾珂[2] 

机构地区：[1]北京和睦家医院神经内科,北京100016 [2]北京市海淀医院北京大学第三医院海淀院区,北京100080

出　　处：《中国实用神经疾病杂志》2016年第8期19-21,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨急性脑梗死(ACI)患者外周血白细胞计数、血清C反应蛋白(CRP)水平的改变及其临床意义。方法选取148例ACI患者及50例健康者为研究对象,测定外周血中白细胞计数和CRP水平。将ACI患者分别根据头颅CT和神经功能损害的程度进一步分组,分析ACI与外周血白细胞、CRP的相关性。结果与对照组比较,急性脑梗组外周血中白细胞和CRP的水平均显著增高,分别是[(10.52±2.17)×109/L vs(6.71±1.82)×109/L,P<0.05]和[(6.31±2.78)mg/L vs(1.78±0.29)mg/L,P<0.05]。且外周血中白细胞计数及CRP水平升高程度与脑梗死体积及神经功能缺损严重程度呈正相关。结论急性脑梗死患者外周血中白细胞计数及CRP水平显著升高,且与脑梗死体积和神经功能缺损严重程度呈正相关。Objective To investigate the effects of peripheral blood leucocyte count and level of serum c-reactive protein （CRP） on acute cerebral infarction （ACI）. Methods Totally 148 cases diagnosed with ACI and 50 healthy controls were recrui ted as research objects to test peripheral blood leucocyte count and CRP level. According to skull CT scan and the degree of neurological function defect, all ACI cases were divided into different subgroups to analyze the association between the pres- ence of ACI and the peripheral blood leucocyte count as well as CRP level. Results Peripheral blood leucocyte count and CRP level in the ACI group were significantly higher than those in the control groups [（10.52±2.17） × 10^9/L vs （6.71±1.82） × 10^9/L, P〈0.05; （6.31±2.78）mg/Lvs （1.78±0.29） rag/L, P〈0.05]. Additionally, both leucocyte count and CRP levels had positive correlations with the degree of neurological function deficit and infarction volume （P〈0.05）. Conclusion Periph eral blood leucocyte count and CRP level are significantly increased in patients with acute cerebral infarction, which have posi- tive correlations with degree of neurological function deficit and infarction volume.

关 键 词：急性脑梗死 白细胞计数 C反应蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]