丁苯酞联合双抗治疗高龄脑梗死患者的安全性分析  

Security analysis of butylphthalide combined with dual antiplatelet treatment on cerebral infarction in elderly

作　　者：孔德强[1] 魏向东[1] 王建桥[1] 李秀云[1] 李战永[2] 

机构地区：[1]廊坊市人民医院神经内科,河北065000 [2]廊坊师范学院生命科学学院

出　　处：《脑与神经疾病杂志》2016年第5期284-287,共4页Journal of Brain and Nervous Diseases

基　　金：河北省廊坊市科学技术研究与发展计划项目(2012013085)

摘　　要：目的分析评估丁苯酞联合阿司匹林及氯吡格雷治疗高龄脑梗死患者的临床安全性。方法109例高龄脑梗死患者,按给予治疗的药物不同分为2组,双抗组(55例):阿司匹林及氯吡格雷联合抗血小板治疗组;丁苯酞组(54例):丁苯酞联合阿司匹林及氯吡格雷抗血小板治疗组。分析丁苯酞组患者给药2w前后的心、肝、肾、凝血功能变化及空腹血糖变化,比较双抗组和丁苯酞组在住院治疗期间药物不良反应的发生情况。结果丁苯酞组给药前后患者心、肝、肾、凝血功能反空腹血糖治疗前后比较差异无统计学意义(P>0.05);丁苯酞组患者在治疗期间的不良反应主要表现为药物治疗1w后谷丙转氨酶、尿素氮升高,停药1w后可恢复正常;给药第2天偶发腹泻、恶心等消化道症状,未经药物处理2d内自行消失。结论应用丁苯酞联合阿司匹林及氯吡格雷短期治疗高龄脑梗死患者具有临床安全性,不良反应轻微可逆。Objective To analyze the safety of butylphthalide in combination with aspirin and clopidogrel treatment on cerebral infarction in elderly.Methods The clinical data of 109 cerebral infarction patients undergoing drug therapies systematically were reviewed.The cases were divided into 2 groups：aspirin and clopidogrel group （ 55 cases）, butylphthalide combined aspirin and clopidogrel group （54 cases）.The function of patient＆#39;s heart, liver and renal as well as coagulation in each group was evaluated.The changes of fasting glucose after treatment and the adverse reactions each case in the course of 2 weeks treatment were analyzed.Rseults By systematic medication therapy, the function of liver, renal, heart and coagulation of patients in butylphthalide combined aspirin and clopidogrel group showed no significant difference pre-and post-administration（P〉0.05）.Additionally, the fasting plasma glucose of patients pre-and post-treatment by butylphthalide were no significant differences（P〉0.05）.The adverse reactions in butylphthalide combined aspirin and clopidogrel group mainly for increasing alanine aminotransferase and blood urea nitrogen in serum 1 week after drug treatment, while these adverse reactions disappeared at1 week after discontinuation.Additionally, occasional diarrhea and nausea administered on day 2 were found but disappeared in2 days without drug treatment.Conclusion The treatment of Butylphthalide combined with aspirin and clopidogrel on elderly cerebral infarction for a short-term was safe.

关 键 词：丁苯酞 阿司匹林 氯吡格雷 脑梗死 高龄患者 安全性 

分 类 号：R743.32[医药卫生—神经病学与精神病学]