c-Met 蛋白在胃肠间质瘤组织中的表达及其临床意义  

Expression of c -Met in gastrointestinal stromal tumor and its clinical significance

作　　者：王超群[1] 黄必飞 王艳[1] 王倩[1] 孙鑫鑫[1] 曾悦[1] 邵俊康 吴丹丹[1] 

机构地区：[1]温州医科大学附属东阳医院东阳市人民医院病理科,浙江省东阳322100

出　　处：《中国基层医药》2016年第10期1453-1455,I0002,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：断江省医药卫生科技计划项目（2012KYB230）

摘　　要：目的：探讨 c-Met 蛋白在胃肠间质瘤（GISTs）组织中的表达，分析其与 GISTs 患者临床病理特征的关系。方法采用免疫组织化学 EnVision 法检测105例 GISTs 组织中 c-Met 蛋白的表达。结果GISTs组织中 c-Met 蛋白阳性率为9．52％（10／105）。c-Met 蛋白表达在核分裂计数＞10个／50HPF 的 GISTs 患者中显著增高（P ＜0．05）；与肿块≤5 cm、胃、极低-低风险 GISTs 相比，c-Met 蛋白表达率在肿块＞5 cm、胃以外部位、中-高风险 GISTs 中较高，但差异无统计学意义（P ＞0．05）。结论c-Met 蛋白表达可能与 GISTs 危险度相关。Objective To study the expression of c -Met protein in gastrointestinal stromal tumor（GIST） and to evaluate its clinicopathological significance.Methods The immunohistochemical technique,EnVision method was used to evaluate the expression of c -Met in 105 cases of GISTs.Results c -Met protein positive rate in GISTs was 9.52%（10 /105）,its expression rate was significantly higher in GISTs with 〉10 /50HPF mitotic activity（P 〈0.05）.c -Met protein expression rate was higher in GISTs which 〉5cm,moderate or high -risk,or mass located outside the stomach,but the difference was not statistically significant（P 〉0.05 ）.Conclusion c -Met protein expression may related with risk of GISTs.We think that c -Met is worthy of further study for its potential usage as a evaluation indicators of GISTs clinicobiological behavior.

关 键 词：C-MET 胃肠间质瘤 免疫组织化学 

分 类 号：R735[医药卫生—肿瘤]