加味金黄散熏洗预防索拉菲尼所致手足皮肤反应的疗效观察  

Observation of the clinical effects of Jiawei Jinhuang powder with fumigation -washing applied for hand-foot skin reaction caused by sorafenib

作　　者：祝朝富 李卓虹[1] 李强[1] 李丹[1] 安佰平[1] 

机构地区：[1]成都中医药大学附属医院肿瘤科,四川省成都610072

出　　处：《中国基层医药》2016年第10期1510-1512,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：观察加味金黄散熏洗预防索拉菲尼所致手足皮肤反应（HFSR）的临床疗效。方法将服用索拉菲尼的患者设为加味金黄散熏洗的治疗组和口服维生素 B6的对照组，每组各24例。8周后对两组HFSR 发病率及分级进行统计对照分析。结果治疗组和对照组 HFSR 发生率、HFSR Ⅱ～Ⅲ发生率比较差异有统计学意义（29．17％比70．83％，χ^2＝8．375，P ＜0．05；12．50％比33．33％，P ＜0．05）。结论加味金黄散能显著降低索拉菲尼所致手足皮肤反应的发生率及减轻手足反应。Objective To investigate associate chief physician the clinical effects of Jiawei Jinhuang powder with fumigation -washing on hand -foot skin reaction（HFSR）caused by sorafenib.Methods 48 patients who received sorafenib were randomly divided into two groups.24 patients in the treatment group were administered Jiawei Jinhuang powder with fumigation -washing,and another 24 patients in the control group were given VitB6 orally.After 8 weeks,the incidence and grade of HFSR were statistically studied between the two groups.Results There was significant differences of hand -foot reaction between the treatment group and the control group （incidence rate：29.17% vs 70.83%,χ^2 =8.375,P 〈0.05;The incidence rate of Ⅱ -Ⅲ：12.50% vs 33.33%,P 〈0.05 ）. Conclusion Jiawei Jinhuang powder with fumigation -washing could remarkably reduce the incidence rate of HFSR caused by sorafenib.

关 键 词：手足皮肤反应 加味金黄散 索拉菲尼 

分 类 号：R730.53[医药卫生—肿瘤]