牛痘疫苗致炎兔皮提取物注射液治疗带状疱疹后遗神经痛的疗效  

Clinical efficacy of extracts from rabbit skin infl amed by vaccinia virus for injection in the treatment of herpes zoster postherpetic neuralgia

作　　者：乔朱卉 王茠茠[1] 应佳昳 张成锋[1] 

机构地区：[1]复旦大学附属华山医院皮肤科,上海200040

出　　处：《世界临床药物》2016年第5期340-343,共4页World Clinical Drug

摘　　要：目的探讨牛痘疫苗致炎兔皮提取物注射液缓解带状疱疹后遗神经痛(PHN)的临床疗效。方法将119例PHN患者随机分为观察组和对照组。观察组肌肉注射牛痘疫苗致炎兔皮提取物注射液3 ml,一日1次注射;对照组口服甲钻胺片,一日3次,每次一片0.5 mg;疗程均为2周。治疗前及治疗第3、7、14天分别采用目测类比评分法(VAS)评定疼痛程度并评价有效率,同时观察治疗过程中的不良反应。结果观察组治疗VAS评分在治疗第3天开始下降,与治疗前和对照组比较,差异具有统计学意义(P<0.05),治疗第7和14天VAS评分下降更为显著(P<0.01)。2周治疗结束后,观察组与对照组有效率分别为90.9%和20.3%,组间差异具有统计学意义(P<0.01)。观察组出现注射部位轻微疼痛1例,不良反应发生率为1.8%。结论牛痘疫苗致炎兔皮提取物注射液用于治疗PHN疼痛,临床疗效显著,起效快,无明显不良反应。Objective To investigate the clinical efficacy of extracts from rabbit skin inflamed by vaccinia virus for injection （Analgecine） in the treatment of herpes zoster postherpetic neuralgia （PHN）. Methods A total of 119 cases of PHN patients were randomly divided into observation group and control group. Patients in observation group were given 3 ml Analgecine intramuscularly once every day for 2 weeks, while patients in control group were given oral mecobalamin, 0.5 mg each time and three times every day for 2 weeks. The extent of pain feeling was assessed by visual analogue scale （VAS） at the 3rd, 7th and 14th day after treatment. The drug adverse reactions were also observed during treatment. Results The VAS scores of observation group were significantly decreased at the 3rd day from first injection and showed significant differences from those of control group and before treatment （P〈0.05）. The VAS scores of observation group were decreased more significantly at the 7th and 14th day from first injection （P〈0.01）. By the end of 2 weeks＇ treatment, the effective rates of observation group and control group were 90.9% and 20.3%, respectively. The differences between two groups were highly significant （P〈0.01）. Only one case （1.8%） in the observation group was reported mild painful feeling in injection site. Conclusion Analgecine has promising effect in the treatment of PHN with rapid onset and there are no obvious adverse reactions observed.

关 键 词：带状疱疹 后遗神经痛(PHN) 牛痘疫苗致炎兔皮提取物注射液(恩再适) 

分 类 号：R741[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]