糖皮质激素:肝病治疗中的双刃剑  

Glucocorticoids,the double-edged sword in the management of liver diseases

作　　者：龙振昼[1] 聂青和[1] 

机构地区：[1]第四军医大学唐都医院全军感染病诊疗中心/传染病科,陕西西安710038

出　　处：《胃肠病学和肝病学杂志》2016年第5期485-489,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：糖皮质激素(glucocorticoids,GCs)由于其强大的抗炎和免疫抑制作用而广泛应用于伴有炎症状态的肝病治疗中。在发挥良好治疗作用的同时,GCs也影响着机体的能量代谢、脂代谢及对压力的应激,引起糖尿病、高血压、肥胖、骨质疏松症及感染等并发症。因此,掌握GCs的应用时机、适应证、禁忌证及发展更好的激素使用优化策略,对最大化患者的治疗收益及最小化不良反应具有重要意义。Glucocorticoids （GCs） remain an important treatment strategy in many liver diseases that accompany with inflammatory conditions, because of their potent anti-inflammatory and immunosuppressive actions. Unfortunately, their clinically desired effects are linked to adverse effects such as disturbance of energy and lipid metabolism and response to stress, and can lead to some complications, for example, diabetes mellitus, hypertension, obesity, osteoporosis and in- fection, and so on. Therefore, shedding light on understanding of the timing, indications and contraindications of use of GCs will favor the maximization of patients＇ therapic benefits, minimization of unwanted effects.

关 键 词：糖皮质激素 肝衰竭 自身免疫性肝病 酒精性肝病 胆汁淤积 病毒性肝炎 

分 类 号：R575[医药卫生—消化系统]