支架植入联合^(125)I粒子近距离放疗对恶性梗阻性黄疸的疗效  

EFFICACY OF ^(125)I PARTICLE BRACHYTHERAPY AFTER STENT IMPLANTATION IN TREATMENT OF MALIGNANT OBSTRUCTIVE JAUNDICE

作　　者：刘帅[1] 武文奇[2] 李子祥[1] 

机构地区：[1]青岛大学附属医院介入医学中心,山东青岛266555 [2]山西医科大学第二附属医院影像科

出　　处：《齐鲁医学杂志》2016年第2期174-176,180,共4页Medical Journal of Qilu

摘　　要：目的观察支架植入联合^(125)I粒子近距离放疗对恶性梗阻性黄疸(MOJ)的疗效。方法回顾性分析2012年12月—2014年12月我院确诊的MOJ病人43例。所有病人均行经皮肝穿刺胆管引流术并植入自膨金属支架,其中17例病人在植入支架同时植入^(125)I粒子条。比较单纯植入支架组(对照组)和支架联合^(125)I粒子条组(观察组)术后支架畅通时间和生存率。结果在平均10.1(5~21)个月随访期内,对照组和观察组支架畅通时间分别为(6.0±3.2)、(9.0±4.5)个月,术后中位生存时间分别为8和11个月,两组差异有统计学意义(Z=3.664、3.176,P<0.05)。结论 ^(125)I粒子条植入近距离放疗是防止支架植入后再狭窄安全、有效的方法,能在一定程度上延长MOJ病人生存期。To observe the efficacy of 125I particle brachytherapy combined with stent implantation for malig nant obstructive jaundice （MOJ）. Methods A retrospective review was done in 43 patients with MOJ confirmed during the pe- riod from December 2012 to December 2014. All the patients underwent pereutaneous biliary drainage （PBD） and implantation of self expanding metal stent （SEMS）, of whom, 17 received implantation of 125I particle while inserting the stent. A comparison was carried out between merely stent-implanting （control group） and combined stent with 125I particle （observation group） in terms of postoperative unblocked time of the stent and survival rate. Results At an average of 10.1 （5--21） months of follow-up, the stent flow time in the control group and the observation group was 6.0--3.2 months and 9.0± 4.5 months, respectively, and the median survival time was 8 months and 11 months, the differenees were statistically significant （Z = 3. 664,3.176 ; P〈 0.05）. Conclusion Insertion of 125I particle bar braehytherapy is safe and effective for preventing restenosis after stent implantation, which can, to a certain extent, prolong the life span of patients with malignant obstructive iaundice.

关 键 词：黄疸 阻塞性 近距离放射疗法 支架 碘放射性核素 治疗结果 

分 类 号：R735.8[医药卫生—肿瘤] R815[医药卫生—临床医学]