C-erB-2、ER、PR在子宫内膜癌中的表达及意义  

Expression and clinical significance of C-erbB-2,ER and PR in adenocarcinoma of endometriuin

作　　者：商庆花 赵岭岭[1] 刘俊芳[2] 吴春平[1] 李景光[1] 刘艳彩 

机构地区：[1]衡水市第四人民医院病理科 [2]衡水市第五人民医院病理科,河北衡水053000

出　　处：《贵州医药》2016年第4期362-364,共3页Guizhou Medical Journal

摘　　要：目的探讨雌激素受体(ER)、孕激素受体(PR)及第二人体表皮生长因子受体(C-erB-2)在子宫内膜癌中的表达及意义。方法应用免疫组化SP法检测三者在30例正常子宫内膜、30例子宫内膜息肉及86例子宫内膜癌组织中的表达水平,分析其临床意义及相关性,并将其与子宫内膜癌手术病理分期、组织细胞学分化程度、肌层浸润深度、淋巴结转移等高危因素进行分析。结果 (1)C-erB-2、ER及PR在正常子宫内膜、子宫内膜息肉和子宫内膜癌中的阳性表达率组与组之间差异均有统计学意义(P<0.05)。(2)C-erB-2阳性表达与手术病理分期、组织细胞学分级及淋巴结转移相关(P<0.05);ER阳性表达与手术病理分期、组织细胞学分级及肌层浸润相关(P<0.05);PR与组织细胞学分级、肌层浸润及淋巴结转移相关(P<0.05)。(3)C-erB-2与ER的表达呈负相关(r=-0.247,P<0.05),ER与PR的表达呈正相关(r=0.756,P<0.05)。结论在子宫内膜癌中,C-erB-2、ER及PR联合检测可作为早期诊断、指导内分泌治疗及判断预后的重要指标。Objective To explore the expression of human epidermal-growth factor receptor 2（C-erB-2）,estrogen receptor（ER）and progesterone receptor（PR）in endometrial carcinoma and their relationship.Methods Immunohistochemical analyses of ER、PR and C-erB-2were performed in 30 cases of normal endometrium,30 cases of endometrial polyps and 86 cases of ndometrial carcinoma cases.The relationship between expression rate and stage of pathology,histoogical grade,myometrial invasion,lymph node metastasis was analyzed.Results There were statistical significantly differences that the positive expression rate between in the groups for the C-erB-2in normal endometrium,endometrial polyps and endometrial carcinoma were significant differences among them（P〈0.05）.There were significant correlation compared with the positive expression of C-erB-2,stage of surgical-pathologic,grade of histocytology,and lymph node metastasis（P〈0.05）.The positive expression of ER was significant correlated with stage of surgical-pathologic,grade of histocytology,and degree of myometrial invasion（P〈0.05）.The positive expression of PR was significant correlation with histocytology,and degree of myometrial invasion（P〈0.05）.The expression of C-erB-2was negatively correlated with the expression of ER in endometrial carcinoma（r=-0.247,P〈0.05）;The expression of ER was positively correlated with the expression of PR in endometrial carcinoma（r=0.756,P〈0.05）.Conclusion The abnormal expression of C-erB-2、ER and PR plays an important role in the occurrence and development of endometrial carcinomas.Both of them may be used as the important index of early diagnosis,guiding therapy of endocrine and judgment of the prognosis of endometrial carcinoma.

关 键 词：子宫内膜腺癌 第二人体表皮生长因子受体 雌激素受体 孕激素受体 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]