动物RNA病毒反向遗传学操作技术及应用进展  

Development and Application of the Reverse Genetics Technology for Animal RNA Viruses

作　　者：孙玉章[1] 倪雪霞[1] 李金明[1] 吴发兴[1] 王永玲[1] 

机构地区：[1]中国动物卫生与流行病学中心,山东青岛266032

出　　处：《中国动物检疫》2016年第5期68-71,共4页China Animal Health Inspection

摘　　要：本文简述了反向遗传操作技术的基本原理以及近年来动物RNA病毒基因复制与表达调控机理、病毒与宿主间的相互作用,以及构建新型病毒载体和研发新型疫苗等方面的研究进展。In this review,the principle of reverse genetics technology was briefly described for animal RNA viruses.Further,the development and the recent advances of this technology were introduced in viral gene replication and regulation mechanism,viral pathogenesis mechanism,virus-hostcell interactions and novel vaccine vectors over the past decades.

关 键 词：动物RNA病毒 反向遗传学 病毒拯救 新型疫苗 应用进展 

分 类 号：S851.3[农业科学—预防兽医学]