围手术期应用胸腺五肽对直肠癌患者免疫功能的影响  

Effect of Application of Thymopentin during Perioperative Period on Immune Function of Patients Undergoing Laparoscopic Assisted Radical Resection for Rectal Carcinoma

作　　者：徐建[1] 邹振玉[1] 邢晓伟[1] 马跃[1] 王玲旳 邹贵军[1] 胡时栋[1] 杜晓辉[1] 

机构地区：[1]解放军总医院普通外科,北京100853

出　　处：《中国普外基础与临床杂志》2016年第5期561-564,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金面上项目(编号:61170123)~~

摘　　要：目的探讨围手术期应用胸腺五肽对行腹腔镜辅助直肠癌根治术患者的免疫功能的影响。方法选取2015年1月至2015年4月期间在解放军总医院普通外科接受腹腔镜辅助腹会阴联合直肠癌根治术患者42例,根据围手术期是否应用胸腺五肽分为研究组和对照组。对照组在围手术期间给予常规治疗;研究组除按对照组的常规治疗外自术前第1 d起给予胸腺五肽2 mg肌注,1次/d,7 d为1个疗程。比较患者术前第1 d、术后第1 d及术后第5 d时的静脉血淋巴细胞计数、免疫球蛋白(Ig G、Ig A和Ig M)及T细胞亚群(CD3^+、CD4^+、CD8^+及CD4^+/CD8^+)的变化情况。结果术后第1 d,2组患者淋巴细胞计数、T细胞亚群及免疫球蛋白较术前均明显降低(P<0.05);术后第5 d时,治疗组淋巴细胞计数、T细胞亚群(除外CD4^+/CD8^+)及免疫球蛋白(除外Ig A)均明显高于对照组(P<0.05),但治疗组的各项指标(淋巴细胞计数、免疫球蛋白、T细胞亚群)的变化情况与术前第1 d时比较差异均无统计学意义(P>0.05),对照组各项指标仍低于术前第1 d(P<0.05)。结论行腹腔镜手术的直肠癌患者围手术期应用胸腺五肽可以加快患者术后免疫功能的恢复。Objective To investigate effect of application of thymopentin during perioperative period on immune function of patients undergoing laparoscopic assisted radical resection for rectal carcinoma. Methods Forty-two patients undergoing laparoscopic assisted radical resection for rectal carcinoma from January 2015 to April 2015 in this hospital were collected. These patients were divided into study group and control group. The patients were received routine treatment in the control group. In addition to routine treatment same as the control group, the patients were received 2 mg thymopentin every day for a week in the study group. The changes of lymphocyte count, T lymphocyte subsets（CD3^＋, CD4^＋, CD8^＋, and CD4^＋/CD8^＋）, and immunoglobulin（Ig G, Ig A, and Ig M） were compared on the 1st day before surgery and on the 1st day and 5th day after surgery. Results The lymphocyte count, T lymphocyte subsets, and immunoglobulin on the first day after surgery were significantly lower than those on the 1st day before surgery in these two groups（P〈0.05）. The lymphocyte count, T lymphocyte subsets（except for CD4^＋/CD8^~＋）, and immunoglobulin（except for Ig A） in the study group were significantly higher than those in the control group on the 5th day after surgery（P〈0.05）. The changes of lymphocyte count, T lymphocyte subsets, and immunoglobulin in the study group had no significant differences between on the 5th day after surgery and on the 1st day before surgery（P〉0.05）, but which on the 5th day afer surgery were significantly lower than those on the 1st day before surgery（P〈0.05） in the control group. Conclusion Application of thymopentin during perioperative period could accelerate recovery of immune function after operation in patientsundergoing laparoscopic assisted radical resection for rectal carcinoma.

关 键 词：围手术期 直肠癌 胸腺五肽 免疫功能 

分 类 号：R735.37[医药卫生—肿瘤]