广西鼻咽癌高发区人群初筛后2年随访结果分析  

Analysis on follow-up results after two years of preliminary screening of polulation from high-risk area of nasopharyngeal carcinoma in Guangxi

作　　者：邓卓霞 翁敬锦[1] 司勇锋[1] 覃扬达[1] 黄波[1] 兰桂萍[1] 王勇利[1] 杨涌[1] 张本坚[1] 韩星[1] 熊伟明[1] 

机构地区：[1]广西壮族自治区人民医院耳鼻咽喉头颈肿瘤科暨鼻咽癌研究所,南宁市530021

出　　处：《广西医学》2016年第4期517-520,共4页Guangxi Medical Journal

基　　金：广西科学研究与技术开发计划项目(桂科攻14124003-3;14279008)

摘　　要：目的 分析广西鼻咽癌高发区初筛2年后鼻咽癌一级亲属和一般人群组血清EB病毒抗体的差异及鼻咽癌发病情况。方法 2013年8~12月广西梧州市、玉林市和南宁市参加鼻咽癌初筛,且2015年8~12月再次接受随访的人群2 022例,对比其初筛时与随访时EB病毒抗体[病毒壳抗原（VCA）-IgA和早期抗原（EA）-IgA]的阳性率,比较鼻咽癌一级亲属（亲属组）和一般人群组中EB病毒抗体的变化及鼻咽癌检出情况。结果 初筛时亲属组VCA-IgA阳性率明显高于一般人群组（P〈0.05）,两组EA-IgA阳性率比较,差异无统计学意义（P〉0.05）。亲属组VCA-IgA变化与一般人群组比较,差异有统计学意义（P〈0.05）;亲属组和一般人群组EA-IgA变化情况,差异无统计学意义（P〉0.05）。随访时亲属组VCA-IgA转阴率明显高于一般人群组（P〈0.05）。随访时两组VCA-IgA、EA-IgA阳性率比较,差异无统计学意义（P〉0.05）。随访时亲属组检出鼻咽癌2例（1.12%）,一般人群组检出10例（0.54%）,两组的鼻咽检出率比较,差异无统计学意义（P〉0.05）。结论 初筛后鼻咽癌一级亲属鼻咽癌检出率并未显著高于一般人群组,可能无需选择性随访。Objective To analyze the difference in the serum Epstein-Barr（EB） virus antibody and the incidence of nasopharyngeal carcinoma（NPC） between first-degree relatives（ FDR group） of NPC patients and general population from the high-risk area of nasopharyngeal carcinoma in Guangxi. Methods A total of 2 022 subjects from Wuzhou City,Yulin City or Nanning City in Guangxi participated in the preliminary screening of Nt~ from August to December 2013 and the follow-up from August to December 2015. The positive rates of EB virus antibodies including virus capsid antigen（VCA ）-IgA and early antigen（ EA ）-IgA when preliminary screening were compared with those when followed up. The changes in EB virus antibodies and the incidence of NPC were compared between FDR group and general population. Results At preliminary screening,the positive rate of VCA-IgA in FDR group was significantly higher than that in the general population（P 〈 0. 05） ,but no significant difference was observed in the positive rate of EA-IgA between two groups（P 〉 0.05）. There was significant difference in the change of VCA-IgA between two groups（P 〈0. 05）,but no significant difference in the change of EA-IgA between two groups （P 〉 0. 05 ）. At follow-up, the negative conversion rate of VCA-IgA in FRD group was obviously higher than that in the general population （P 〈 0. 05 ）. At follow-up, there were no significant differences in the positive rates of VCA-IgA or EA-IgA between two groups （P 〉 0.05 ）. At follow-up ,2 cases （ 1.12% ） and 10 cases （0.54%） of NPC were found in FRD group and general population respectively,and there was no significant difference in the detection rate of NPC between FRD group and general population（P 〈0.05）. Conclusion The detection rate of NPC in FDR is not significantly higher than that in the general population after preliminary screening, and FDR of NPC patients may not need the selective follow-up.

关 键 词：鼻咽癌 EB病毒抗体 筛查 一级亲属 随访 广西 

分 类 号：R739.63[医药卫生—肿瘤]