替吉奥联合康艾注射液治疗晚期非小细胞肺癌的临床效果  

Clinical effectiveness of S-1 combined with Kang'ai Injection in the treatment of advanced non-small cell lung cancer

作　　者：杨君[1] 韩莹[2] 王爱辉[3] 郭晓辉[1] 

机构地区：[1]河北港口集团有限公司港口医院肿瘤科,河北秦皇岛066000 [2]河北港口集团有限公司港口医院检验科,河北秦皇岛066000 [3]河北省秦皇岛市第三医院检验科,河北秦皇岛066000

出　　处：《中国医药导报》2016年第13期125-128,共4页China Medical Herald

基　　金：河北省秦皇岛市市级科技计划项目(201401A173)

摘　　要：目的比较替吉奥联合康艾注射液与多西他赛治疗晚期非小细胞肺癌(NSCLC)的临床效果和安全性。方法回顾性分析了河北港口集团有限公司港口医院2010年1月~2015年3月96例经一线和/或二线化疗失败的晚期NSCLC患者采用区组随机化法分为联合康艾注射液组(A组)和多西他赛组(B组),每组48例。A组:替吉奥80 mg/(m2·d),分2次口服,康艾注射液60 m L,静滴qd,d1-14,B组:多西他赛75 mg/m2,静滴d1,21 d为一个周期。结果两组的中位总生存(OS)分别为9.5个月和10.0个月,中位无进展生存(PFS)分别为2.8个月和4.2个月;两组的客观缓解率(ORR)分别为6.25%和8.33%,疾病控制率(DCR)分别为39.58%和43.75%。差异无统计学意义(P>0.05)。A组在血液学毒性、恶心呕吐、乏力、感染性发热等方面的不良反应明显低于B组(P<0.05)。结论替吉奥联合康艾注射液与多西他赛治疗晚期NSCLC的效果相当,但毒副作用较低,耐受性更好,适用于晚期NSCLC的临床治疗。Objective To compare the efficacy and safety of S‐1 plus Kang＇ai injection and docetaxel in the treatment of advanced non-small cell lung cancer（NSCLC）. Methods 96 patients with the failure of one or more regimens of systemic chemotherapy in Hebei Port Holdings Limited Port Hospital from January 2010 to March 2015 were retrospectively studied and divided into S-1 plus Kang＇ai Injection group（group A） and Docetaxel group（group B） by block randomization, with 48 cases in each group. group A： received oral S-1（80 mg/m^2） in two divided doses daily and Kang＇ai injection（60 m L/d） as an iv infusion, qd, on days 1–14; group B： received docetaxel（75 mg/m^2） intravenously on day 1. Repeated every 21 days. Results The median OS of two groups were 9.5 months and 10.0 months, and the median PFS of two groups were 2.8 months and 4.2 months respectively. The ORR of two groups were 6.25% and8.33%, and the DCR of two groups were 39.58% and 43.75% respectively. The difference was not statistically significant. The adverse reactions of group A in hematological toxicity, nausea, vomiting, fatigue and infectious fever were significantly lower than those of group B（P〈 0.05）. Conclusion Clinical effectiveness of S-1 plus Kang＇ai injection and docetaxel in the treatment of advanced NSCLC is equal, but the toxicity is lower, and the tolerance is better, and it is suitable for the clinical treatment of advanced NSCLC.

关 键 词：替吉奥 康艾注射液 多西他赛 晚期非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]