喉癌中神经介素U过表达与区域淋巴结转移相关性研究  

Neuromedin U expression related to the occurrence of laryngeal carcinoma and the regional lymph node metastasis

作　　者：王亚平[1] 陈晨[2] 李玲香[1] 崔晓波[1] 徐明义[1] 

机构地区：[1]内蒙古医科大学附属医院耳鼻咽喉科,呼和浩特010059 [2]武汉大学人民医院耳鼻咽喉头颈外科研究所

出　　处：《临床耳鼻咽喉头颈外科杂志》2016年第10期811-814,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:神经介素U(NMU)在多种组织和器官具有免疫调节作用,本研究拟探讨其与喉癌局部转移的相关性。方法:采用免疫组织化学方法检测240例喉癌患者原发灶组织中NMU的表达差异,随后采用组织芯片(TMA)扩大样本量进一步分析NMU蛋白表达与喉癌患者T、N、M分期的相关性。结果:240例喉癌患者中51.4%的患者出现颈部淋巴结转移。出现局部转移的患者中原发灶中NMU的表达显著高于无转移患者,且随着肿瘤分期进展,NMU表达显著增加。结论:NMU在喉癌中的表达与喉癌局部转移及喉癌TNM分期显著相关,提示NMU可能参与喉癌的进展及转移过程。Objective：Neuromedin U（NMU）plays important role in immune regulation in a variety of tissues and organs,and this study intends to explore the correlation between the local metastasis of laryngeal cancer and the expression of NMU.Method：A retrospective analysis was made on 240 cases of laryngeal carcinoma in our hospital.The expression of NMU was detected by immunohistochemistry.Microassay tissue（TMA）was used to further analyze the correlation of NMU protein expression with T,N and M stage in laryngeal carcinoma.Result：Cervical lymph node metastasis was present in 51.4% of 240 laryngeal carcinoma patients.The expression of NMU was significantly higher in the patients with local metastasis than those without metastasis.And along with tumor progression,NMU expression increased significantly.Conclusion：The expression of NMU in laryngeal carcinoma was significantly correlated with the metastasis of laryngeal carcinoma and TNM stage,which indicated that NMU may be involved in the development of laryngeal carcinoma metastasis.

关 键 词：神经介素U 局部转移 喉癌 生物标志物 组织芯片 

分 类 号：R739.61[医药卫生—肿瘤]