线粒体靶向抗肿瘤药物及其分类  

Anti-tumour Drug Targeting to Mitochondrion and Its Classification

作　　者：潘凌立[1] 李东巍[2] 雷克林[3] 

机构地区：[1]鄂东医疗集团黄石市中心医院(湖北理工学院附属医院)急诊科,湖北黄石435002 [2]武汉大学化学与分子科学学院,湖北武汉430072 [3]湖北文理学院化学工程与食品科学学院,湖北襄阳441053

出　　处：《化学与生物工程》2016年第5期6-11,14,共7页Chemistry & Bioengineering

基　　金：湖北省自然科学基金资助项目(2013CFC027)

摘　　要：线粒体是真核细胞重要的细胞器,在细胞代谢中发挥主要作用。线粒体与疾病的发生、发展、治疗密切相关,线粒体靶向抗肿瘤药物分子的设计和研究已成为药学、化学和生命科学等领域的关注热点。分别简述了8类线粒体靶向抗肿瘤药物的作用机制和特征,介绍了2类新型多功能线粒体靶向抗肿瘤药物,并展望了抗肿瘤药物未来的发展方向。Mitochondrion is an important organelle in eukaryotic cells and plays a central role in cellular metabolism.The mitochondria are closely related to the occurrence,development and treatment of diseases.Design and research on anti-tumour drug molecules targeting to mitochondrion have become a hotspot in pharmacy,chemistry and life sciences,etc..In this paper,interaction mechanism and characteristics of eight species of antitumour drugs targeting to mitochondrion are introduced.Two species of new multifunctional anti-tumour drugs targeting to mitochondrion are also introduced.And the directions for future development of anti-tumour drugs are prospected.

关 键 词：线粒体 靶向药物 抗肿瘤 分类 

分 类 号：R730[医药卫生—肿瘤]