视网膜小胶质细胞在年龄相关性黄斑变性中的免疫调节作用  

The immunomodulatory role of retinal microglial cells in age-related macular degeneration

作　　者：张鹏飞[1] 孙晓东[1] 

机构地区：[1]上海交通大学附属第一人民医院眼科上悔市眼底病重点实验室,200080

出　　处：《中华眼科杂志》2016年第5期386-390,共5页Chinese Journal of Ophthalmology

摘　　要：AMD是老年人的主要致盲眼病之一。近年来研究发现，视网膜小胶质细胞在AMD的发病中扮演了重要角色，其活化和极化状态可以影响病程的发展。本文就视网膜小胶质细胞对AMD的免疫调节作用进行综述，以期探讨其发生机制，为AMD的防治提供新的思路。Age-related maeular degeneration （AMD） is one of the major causes of visual impairment in the elder population. Recent studies have revealed that retinal microgliaeytes may play an important role in the pathogenesis of AND, and the activation of retinal mieroglia could regulate the progress of AND. The immunomodulatory role of retinal microglial cells is reviewed in this article, so as to investigate the mechanism and provide new insight for prevention and treatment of AND.

关 键 词：黄斑变性 视网膜 小神经胶质细胞 免疫调节 

分 类 号：R774.5[医药卫生—眼科]