细胞自噬与眼部疾病发生的关系  

The relationship between autophagy and ocular diseases

作　　者：张璐[1,2] 谢立信[2] 

机构地区：[1]山东大学医学院,济南250012 [2]山东省医学科学院山东省眼科研究所

出　　处：《中华眼科杂志》2016年第5期391-395,共5页Chinese Journal of Ophthalmology

摘　　要：细胞自噬是指将受损、变性和衰老的蛋白质与异常细胞器运送至溶酶体进行消化降解的过程，是真核细胞内降解的重要途径。细胞自噬功能缺陷会导致多种人体疾病，如癌症、年龄相关疾病、感染性疾病和神经变性疾病等。研究表明细胞自噬相关蛋白质在眼部持续表达，异常的细胞自噬是多种眼部疾病的重要病理学特征。细胞自噬和眼部疾病发生之间的关系亟待深入研究，尤其与白内障的关系，这将有助于更好地认识和治疗这些疾病。本文将针对目前关于细胞自噬和眼部疾病之间关系的研究进展进行阐述。Autophagy is an intracellular degradative process used by eukaryotes that delivers cellular constituents to lysosomal degradation, such as damaged, degenerated or long-lived proteins, and excessive or defective organelles. Dysfunction of autophagy is involved in many human diseases, such as cancers, ageing, infectious and neurodegenerative diseases. A number of studies have shown that autophagy- related proteins are constitutively expressed in the eye, and abnormal autophagy is an important pathological feature of some ocular diseases. This article reviews reeent advances in understanding the role of autophagy in the pathogenesis of ocular diseases, including cataract.

关 键 词：自噬 白内障 角膜疾病 眼疾病 

分 类 号：R77[医药卫生—眼科]