城乡接合部地区梅毒患者血清标志物检测及临床特征分析  

Serum markers testing and clinical feature with syphilitic patients in urban-rural areas

作　　者：周腾坚 杜季梅[1] 楼永良[1] 陈海强 

机构地区：[1]温州医科大学检验医学院,浙江温州325000 [2]浙江省永嘉县人民医院检验科,浙江永嘉325100 [3]浙江省温州市鹿城区人民医院检验科,温州鹿城325000

出　　处：《中国农村卫生事业管理》2016年第5期587-590,共4页Chinese Rural Health Service Administration

摘　　要：目的：分析城乡接合部地区梅毒患者血清标志物检测情况和临床特征，为该地区梅毒的预防和治疗提供参考依据。方法：对地处温州市城乡接合部的鹿城区人民医院和非城乡接合部的永嘉县人民医院2015年年龄区间在16～55岁的门诊和住院患者进行梅毒螺旋体颗粒凝集试验（TPPA）、甲苯胺红不加热血清反应素试验（TRUST）、乙型肝炎表面抗原（HBsAg）、抗人类免疫缺陷病毒抗体（HIV）和抗丙型肝炎病毒抗体（HCV）测定，查阅阳性患者的电子病历，明确其梅毒分期，并对各数据进行统计比较。结果：鹿城区人民医院TPPA、TRUST、HBsAg、抗HIV抗体、抗HCV抗体阳性率高于永嘉县人民医院，TPPA阳性率差异具有统计学意义（P〈0．001）。两地TPPA阳性率均以26～35岁最高，TRUST阳性率男女性别间差异不具有统计学意义（P〉0．05），但阳性人数均随着效价的升高而下降。梅毒分期方面，城乡接合部地区显性梅毒比例高于非城乡接合部地区，差异具有统计学意义（P〈0．05）。结论：作为城市化进程中的一个特殊区域，城乡接合部地区的梅毒和传染性疾病感染高发，类似地区梅毒的防治需引起足够的重视，应加强宣教力度和预防措施，控制当地传染病疫情，以利于社会和谐。Objective To analyze the serum markers detection and clinical characteristics of patients with syphilis in urban--rural areas and to provide reference for the prevention and treatment of syphilis in the region. Methods Outpa- tients and inpatients aged 15 ~ 55 treated in Lucheng District People＇s Hospital （located in Wenzhou urban--rural area） and Yongjia County People＇s Hospital （located in non--urban--rural area） in 2015 were selected. Treponema pallidum particle agglutination test （TPPA）,toluidine red unheated serum reagin （TRUST）, hepatitis B surface antigen （biB sAg） ,antibodies against human immunodeficiency virus （HIV） and antibody to hepatitis C virus （HCV） were tested. Besides,electronic medical records of positive patients were checked;syphilis stages were identified and statistical comparison was conducted on various data. Results TPPA, TRUST, HBsAg, HIV antibody and anti HCV antibody positive rate of patients from Lucbeng District People＇s Hospital were higher than those of patients from Yongjia County People ＇s Hospital and TPPA was statistically significantly different（P〈0. 001）. Moreover, patients aged 26--35 in both hos pitals had the highest positive rate of TPPA and the positive rate of TRUST was not statistically significantly different between male and female（P〉0. 05）. However, the number of patients with positive TRUST decreased with the in- crease of titer. As for syphilis staging,the dominant syphilis ratio in urban--rural area was higher than that in non-- rural--urban area, with statistically significant differences（P〈0.05）. Conclusions There is high incidence of syphilis in- fection and infectious diseases in rural--urban area, a special area in the urbanization process. People should pay enough attention to the syphilis prevention and control in similar areas, strengthen the promotion and education and take pre- ventive measures to control the local outbreaks of infectious diseases.

关 键 词：城乡接合部 梅毒 艾滋病 乙肝 丙肝 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]