G-CSF动员造血干细胞机制研究进展  

Research progress on the hematopoietic stem cell mobilization mechanism of G-CSF

作　　者：李程程 孟爱民 

机构地区：[1]中国医学科学院医学实验动物学研究所,北京100021

出　　处：《生命科学》2016年第4期480-485,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81372928;81129020)

摘　　要：人类粒细胞集落刺激因子(granulocyte colony-stimulating factor,G-CSF)是临床上广泛应用的细胞因子之一,最早用于治疗中性粒细胞减少症,降低癌症患者化疗后的死亡率。在临床应用中发现,其可以有效地动员骨髓中造血干细胞进入外周血,目前是临床上最常用的造血干细胞动员剂。介绍了G-CSF的生物学特性,并详细阐述了G-CSF动员造血干细胞的机制,为临床上G-CSF提高动员效率、减少副作用,以及为新型造血干细胞动员剂的开发提供理论基础。G-CSF has been widely used in clinical, and it is not only used to treat neutropenia, but also used to reduce the mortality of cancer patients after chemotherapy. What＇s more, G-CSF is the most widely used hematopoietic stem cell （HSC） mobilization agent at present. The review introduced the biology of G-CSF, and focused on the HSC mobilization mechanism of G-CSF. To explore the exact mechanism is necessary to improve the efficiency of G-CSF mobilization, and to provide a theoretical basis for the development of new hematopoietic stem cell mobilization agents in the future.

关 键 词：人类粒细胞集落刺激因子 动员造血干细胞 机制 蛋白酶 脂类 

分 类 号：R733[医药卫生—肿瘤] R73-35[医药卫生—临床医学]