^(18)F-FDG PET-CT在NK/T细胞淋巴瘤诊断与鉴别诊断中的价值  

The value of ^(18)F-FDG PET-CT for the diagnosis of natural killer/T-cell lymphoma

作　　者：甄玉莎 徐文贵[1] 宋秀宇[1] 戴东[1] 朱磊[1] 朱湘[1] 马文超[1] 

机构地区：[1]天津医科大学肿瘤医院分子影像及核医学诊疗科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津300060

出　　处：《中国实验诊断学》2016年第4期547-550,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨^(18)F-FDG PET-CT在NK/T细胞淋巴瘤诊断与鉴别诊断中的价值。方法回顾性分析39例临床疑似NK/T细胞淋巴瘤的PET-CT显像结果,并与头颈部鳞癌和其他类型非霍奇金淋巴瘤(NHL)等比较。结果39例患者中,经病理证实,共有35例真阳性患者,1例假阳性患者,3例真阴性患者。PET-CT对NK/T细胞淋巴瘤诊断的准确度为97.4%(38/39),灵敏度为100%(35/35),特异度为75.0%(3/4),阳性预测值为97.2%(35/36),阴性预测值为100%(3/3)。NK/T细胞淋巴瘤与头颈部鳞癌两组疾病鼻咽部的SUVmax相比较,P值>0.05,差异无统计学意义。NK/T细胞淋巴瘤与其他类型NHL两组疾病鼻咽部的SUVmax相比较,P值均>0.05,差异无统计学意义。在NK/T细胞淋巴瘤、头颈部鳞癌、其他类型NHL这三组病例中,病灶位于鼻咽部的病例分别为18、22、25例,位于颈部淋巴结者分别为18、20、16例。此外,NK/T细胞淋巴瘤病灶位于鼻腔者共21例,累及鼻甲者8例、副鼻窦8例、口咽9例。头颈部鳞癌患者的病灶位于鼻咽者共22例,累及头颈部淋巴结者20例。其他类型的NHL,病灶部位侵犯全身淋巴结25例、口咽18例、脾脏16例。结论 NK/T细胞淋巴瘤鼻咽部的SUVmax与头颈部鳞癌及其他类型NHL比较,无显著差异。三组病例病灶均最常见于鼻咽部,但NK/T细胞淋巴瘤病灶还常见于鼻腔,头颈部鳞癌的病灶基本仅位于鼻咽部和颈部淋巴结,其他类型NHL的病灶常侵犯全身淋巴结、口咽和脾脏。Objective To investigate the diagnostic value of ^（18）F-FDG PET-CT imaging in natural killer/T-cell lymphoma.Methods A retrospective analysis of 39 clinically suspected natural killer/T-cell lymphoma patients examined by PET-CT,and compared respectively with squamous carcinoma in head and neck（SCCHN）and other non-Hodgkin lymphoma（NHL）.Results Of the total 39 analyzed cases,35 patients were confirmed to have natural killer/T-cell lymphoma.The agreement rate,sensitivity,specificity,positive predictive value,negative predictive value were 97.4%,100%,75.0%,97.2%,100%.For the SUVmax,compared with SCCHN and other NHL（P0.05,both）,the difference was not statistically significant.In the three groups of natural killer/T-cell lymphoma,SCCHN and other NHL,the lesions in nasopharyngeal respectively were 18,22,25 cases,in the lymph nodes of neck were 18,20,16 cases.What＇s more,for the natural killer/T-cell lymphoma,the lesions involved nasal cavity,nosepiece,sinuses paranasales,oropharyngeal respectively were 21,8,8,9cases.For the SCCHN,the lesions in the lymph nodes of neck were 20 cases.For the other NHL,the lesions involved lymph nodes of body as a whole,oropharyngeal,spleen respectively were 25,18,16 cases.Conclusion The SUVmax of natural killer/T-cell lymphoma compared with SCCHN and other NHL,the difference was not statistically significant.For the three groups,the most lesions were in nasopharyngeal.However,the lesions of natural killer/T-cell lymphoma also involved nasal cavity.The lesions of SCCHN only involved nasopharyngeal and the lymph nodes of neck almost.The lesions of other NHL commonly involved lymph nodes of body as a whole,oropharyngeal,spleen respectively also.

关 键 词：NK/T细胞淋巴瘤 18F-FDG PET-CT 诊断 

分 类 号：R733.1[医药卫生—肿瘤]