角膜胶原交联治疗角膜融解的研究进展  

Progress of research on corneal collagen cross-linking for corneal melting

作　　者：肖可人 何书喜[2] 

机构地区：[1]南华大学医学院,中国湖南省衡阳市421001 [2]湖南省人民医院眼视光学中心,中国湖南省长沙市410005

出　　处：《国际眼科杂志》2016年第6期1060-1062,共3页International Eye Science

摘　　要：角膜胶原交联(corneal collagen cross-linking,CXL)技术是通过紫外光A和感光剂核黄素的光化学反应使角膜基质内胶原纤维形成共价键,从而增加胶原纤维机械强度、生物学稳定性及角膜抗扩张能力。角膜融解(corneal melting)是一种与自身免疫相关的非感染性角膜溃疡。我们对角膜融解发病机制、目前主要治疗手段及紫外光A核黄素介导角膜胶原交联术基本原理、在角膜融解方面的实验和临床研究现状等问题进行综述。Corneal collagen cross-linking（ CXL） could increase the mechanical strength, biological stability and halt ectasia progression due to covalent bond formed by photochemical reaction between ultraviolet-A and emulsion of riboflavin between collagen fibers in corneal stroma. Corneal melting is an autoimmune related noninfectious corneal ulcer. The mechanismof corneal melting, major treatment, the basic fundamental of ultraviolet-A riboflavin induced CXL and the clinical researches status and experiment in CXL were summarized in the study.

关 键 词：角膜胶原交联 核黄素 紫外光A 角膜融解 

分 类 号：R772.2[医药卫生—眼科]