E-cadherin和Slug在口腔鳞状细胞癌中的表达及临床意义  

Expression and Clinical Significance of E-cadherin and Slug in Oral Squamous Cell Carcinoma

作　　者：郑彩云[1] 汪鹏[1] 沈显军[1] 王舒仪 郑海红[2] 施更生[1] 

机构地区：[1]温州医科大学附属台州医院口腔科,317000 [2]温州医科大学附属台州医院病理科,317000

出　　处：《医学研究杂志》2016年第5期115-119,共5页Journal of Medical Research

基　　金：台州市医学会研究基金资助项目(TZSYXH15-13)

摘　　要：目的研究E-cadherin和Slug在口腔鳞状细胞癌(OSCC)组织中的表达及临床意义。方法采用免疫组织化学DAB显色法检测74例OSCC组织切片和30例正常口腔黏膜组织切片中E-cadherin和Slug的表达,分析E-cadherin与Slug在OSCC和正常口腔黏膜组织中的表达及E-cadherin与Slug的异常表达与临床病理特征之间的关系。结果在OSCC组织中E-cadherin和Slug的阳性表达率分别为52.63%(40/74)和48.65%(36/74)。结合OSCC临床病理特征发现,E-cadherin的表达与肿瘤病理分级、淋巴结转移有统计学意义(P<0.05),Slug的表达与肿瘤病理分级、TNM分期、淋巴结转移有统计学意义(P<0.05),同时发现OSCC组织中E-cadherin的表达与Slug的表达呈负相关(r=-0.513,P<0.05)。结论 E-cadherin和Slug的表达异常可能与OSCC的发生、发展、转移相关,其二者的联合检测可作为判断OSCC恶性程度和预后的参考指标。Objective To explore the expression and the prognostic significance of E - cadherin and Slug in oral squamous cell carcinoma（OSCC） tissues. Methods We analyzed the E - cadherin, Slug expression in 74 patients with OSCC and 30 normal oral tissue by means of immunohistochemistry. Results E - cadherin, slug positive expression rate in OSCC was 52.63 （40/74） and 48.65% （ 36/ 74 ）. The results of clinical and pathological characteristics in OSCC showed that the expression of E - cadherin were associated with pathological and lymph node metastasis（P 〈 0. 05） , while the the expression of Slug were associated with pathological, TNM stage and lymph node metastasis（P 〈 0.05 ）. The results also suggested that the expression of E - eadhein and Slug had a negative correlation （ r = - 0. 513 ,P 〈 0.05 ）. Conclusion Expression of E - cadherin and Slug may correlate with occurrence, development and metastasis of OS- CC. The expression of E - eadherin and Slug can be regarded as valuable indicators for evaluating biological behavior and the prognosis of OSCC.

关 键 词：E—cadherin SLUG EMT 口腔鳞状细胞癌 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]