OX40L和ICAM-1在子痫前期患者外周血中的表达水平及意义  

The Expression Levels and Significances of OX40L and ICAM-1 in Peripheral Blood of Preeclampsia Patients

作　　者：苗露[1] 杨海澜[2] 韩方[2] 马惠静[2] 秦静[2] 

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学第一医院

出　　处：《中国医学创新》2016年第14期86-89,共4页Medical Innovation of China

摘　　要：目的:通过检测子痫前期患者外周血中协同刺激分子(OX40L)和细胞间黏附分子(ICAM-1)的水平,探讨OX40L和ICAM-1在子痫前期发生机制中的作用。方法:选择本院2014年4月-2014年8月收治的40例重度子痫前期(重度子痫前期组)和35例正常孕妇(对照组)为研究对象,采用酶联免疫吸附法(ELISA)测定其血清中OX40L和ICAM-1的水平,比较两组患者细胞因子水平。结果:重度子痫前期组OX40L、ICAM-1在外周血的表达与对照组比较均有所增强,差异均有统计学意义(P<0.05)。结论:重度子痫前期组OX40L、ICAM-1的表达增强可能与子痫前期的发生、发展有关。Objective：To discuss the role of OX40L and ICAM-1 in the pathogenesis of preeclampsia by examining OX40L and ICAM-1 levels in peripheral blood of patients with preeclampsia.Method：Forty cases of severe preeclampsia（the severe preeclampsia group） and thirty-five cases of normal pregnancy women（the control group） admitted to our hospital from April 2014 to August 2014 were selected as the objects,then whose OX40L and ICAM-1 levels were detected and compared by ELISA method.Result：The OX40L and ICAM-1 values of the severe preeclampsia group were significantly increased compared with the control group,the differences were statistically significant（P〈0.05）.Conclusion：The expression of OX40L and ICAM-1 increased in severe preeclampsia group may be associated with the pathogenesis and development of preeclampsia.

关 键 词：OX40L CAM-1 外周血 重度子痫前期 发病机制 

分 类 号：R714.244[医药卫生—妇产科学]