氟甲喹的波谱学数据与结构确证  

Spectral Analysis and Structural Confirmation of Flumequine

作　　者：李永利[1] 李杰[1] 许卓妮 王东辉[1] 陈鹰[1] 

机构地区：[1]上海市计量测试技术研究院,上海201203

出　　处：《中国兽药杂志》2016年第5期29-33,共5页Chinese Journal of Veterinary Drug

基　　金：上海市技术性贸易措施应对专项项目(14TBT007;15TBT009)

摘　　要：建立了一种仪器分析技术确证氟甲喹化学结构的方法。采用紫外光谱(UV)、红外光谱(IR)、质谱、一维(1H、13C、DEPT)和二维(HSQC、HMBC、1H–1H COSY)核磁共振谱、热重分析(TGA)、差示扫描量热法(DSC)以及X—射线粉末衍射(PXRD)对氟甲喹进行结构分析。讨论了紫外和红外吸收特征峰,详细归属了所有的1H-NMR和13C-NMR信号,并对热分析(TGA/DSC)结果进行了解析,确定了与晶型相关的不同衍射角的特征衍射峰。以上研究结果确证了氟甲喹的化学结构。A method for determination of chemical structure of flumequine was established. The structure was elucidated by UV,IR,MS,1D NMR（^1H,^13 C,DEPT） and 2D NMR（ HSQC,HMBC,^1H –^1H COSY）,DSC,TGA,and PXRD. The UV and IR absorption peaks were discussed,and all the signals of1H- NMR and13 C NMR were attributed to their respective structures and positions in the molecule. The test result of TGA / DSC was analyzed,and the diffraction peaks of the different diffraction angles related to the crystal form were determined. The experiment verified that the chemical structure of this compound is flumequine.

关 键 词：氟甲喹 波谱学 波谱特征 结构确证 

分 类 号：R917[医药卫生—药物分析学]