68例小儿脑性瘫痪的危险因素分析  

Risk factors analysis of 68 cases of children with cerebral palsy

作　　者：彭素华[1] 李静[1] 吴樊[1] 王冬梅[2] 

机构地区：[1]首都医科大学怀柔教学医院康复科,北京101400 [2]首都医科大学怀柔教学医院儿童保健科

出　　处：《中华全科医学》2016年第7期1163-1165,共3页Chinese Journal of General Practice

摘　　要：目的探讨小儿临床发生脑性瘫痪的危险致病因素,为其临床治疗提供数据参考。方法选择我区残联2014年8月—2015年8月间收治的68例脑性瘫痪患儿为观察组,并选取同期保健科体检的136例正常儿童为对照组。以1∶2配比病例对照的方式进行本项研究。制定危险因素调查表,对2组儿童父亲吸烟情况;母亲生育年龄、家族病史、怀孕次数、生产次数、孕前月经状况、营养保健状况、孕期疾病状况、分娩方式;新生儿早产、出生体重、新生儿窒息、新生儿感染、核黄疸、新生儿缺氧缺血性脑病等情况进行统计,并采用单因素和多因素分析确定小儿脑性瘫痪的危险因素。结果单因素结果显示母亲生育年龄、家族史、早产、新生儿出生体重、新生儿窒息、核黄疸、缺氧缺血性脑病是小儿发生脑性瘫痪的单因素危险因素。多因素Logistic回归分析结果显示:母亲生育年龄、家族史、早产、新生儿出生体重、新生儿窒息、核黄疸、缺氧缺血性脑病等是小儿发生脑性瘫痪的危险因素。结论近年来,小儿脑性瘫痪的发病率逐年提高,其临床发病由多种因素共同作用引起。其中,母亲生育年龄、家族史、早产、新生儿出生体重、新生儿窒息、核黄疸、缺氧缺血性脑病是小儿脑性瘫痪的高危因素,明确脑瘫高发人群,为其早期康复介入提供流行病学依据。Objective To investigate the risk factors of children with cerebral palsy and provide reference data for clinical treatment. Methods Total 68 cases of children with cerebral palsy in our hospital from August,2014 to August,2015 were assigned into observation group, and 136 healthy children in medical and health department for health examination in the same period were recruited into control group. This study was carried out by ways of 1：2 matched methods. The fac- tors of father smoking status, mother childbearing age, family history, pregnancies number, production times, pre-pregnancy menstrual status, nutritional status, pregnancy disease status, delivery mode, premature birth, birth weight, neonatal asphyx- ia, neonatal infection, kernicterus, and neonatal hypoxic-ischemic encephalopathy of two groups were accounted and ana- lyzed by univariate and multivariate analyzes. Results Univariate analysis results showed：mother childbearing age, family history, premature birth, birth weight, neonatal asphyxia, kernicterus, and hypoxic-ischemic encephalopathy were the inde- pendent risk factors for children with cerebral palsy. Multivariate Logistic regression analysis results showed：mother child- bearing age, family history, premature birth, birth weight, neonatal asphyxia, kernicterus, and hypoxic-ischemic encephalop- athy are the multivariate risk factors for children with cerebral palsy. Conclusion In recent year, incidence rate of chil- dren cerebral palsy is increasing year by year, children cerebral palsy is caused by collective effect of variety factors in clinical. The mother childbearing age ,family history, premature birth, birth weight, neonatal asphyxia, kernicterus, and hy- poxic-ischemic encephalopathy are the risk factors for children with cerebral palsy. This show the high incidence popula- tion of cerebral palsy and provide an epidemiological evidence for early rehabilitation on them.

关 键 词：小儿 脑性瘫痪 危险因素 

分 类 号：R742.3[医药卫生—神经病学与精神病学] R725[医药卫生—临床医学]