原位型乳头状汗管囊腺癌  

A case of syringocystadenocarcinoma papilliferum in situ

作　　者：李彦希[1] 朱小娟[1] 黎智[1] 阎衡[1] 

机构地区：[1]重庆市中医院皮肤科,重庆400011

出　　处：《临床皮肤科杂志》2016年第6期433-435,共3页Journal of Clinical Dermatology

摘　　要：报告1例原位型乳头状汗管囊腺癌。患者男,64岁。腰部斑块10年,增大1年。皮肤科检查:腰部一直径约10 cm斑块,颜色淡红,表面潮湿、不光滑,触之较硬。皮损组织病理检查:表皮角化过度伴角化不全,浆痂形成,部分表皮向下凹陷形成囊腔样结构,可见乳头状突起,囊壁由复层鳞状上皮构成,细胞排列紊乱,部分细胞核大深染,可见病理性核分裂象,间质内见大量浆细胞。免疫组化检查:癌胚抗原(CEA)、上皮膜抗原(EMA)、角蛋白(CK)7陷窝处局灶阳性,核增殖抗原(Ki-67)约60%阳性,P63阳性,巨囊病性液体蛋白(GCDFP)-15阴性,诊断:原位型乳头状汗管囊腺癌。A case of syringocystadenocarcinoma papilliferum in situ is reported. A 64-year-old man presented with plaque on the waist for 10 years, and the plaque became larger for 1 year. Physical examination revealed a 10 cm diameter, hard erythema with rough, moist surface on the waist. Histopathological examination showed the epidermal hyperkeratosis accompanied by parakeratosis, scab formation, cystic invagination downward from the epidermis and papillary protrusion. The cyst walls were consisted of multiple layers of irregularly arranged squamous epithelial cells, part of which were with large hyperchromatic nuclei, and pathological mitoses. A large number of plasma cells were found in the stroma. Immunohistoehemical staining showed focal positive for CEA, EMA, CK7, Ki-67（=60%）, and p63, and negative for GCDFP-15. The diagnosis of syringocystadenocarcinoma papilliferum in situ was made.

关 键 词：乳头状汗管囊腺癌 原位 

分 类 号：R736.1[医药卫生—肿瘤]