季节变化对消化性溃疡内镜检出率的影响：一项单中心10年内镜数据回顾研究  

Seasonal variation of peptic ulcer disease in eastern China-a 10-year single center retrospective study

作　　者：王天骄[1] 高绥之 夏士博 赵朕华 朱曙光[1] 苏松[1] 王东[1] 吴仁培[1] 綦珂[1] 李淑德[1] 王洛伟[1] 杜亦奇[1] 刘枫[1] 金震东[1] 邹多武[1] 廖专[1] 李兆申[1] 

机构地区：[1]第二军医大学附属长海医院消化内科,上海200433

出　　处：《中华消化内镜杂志》2016年第5期291-295,共5页Chinese Journal of Digestive Endoscopy

摘　　要：目的探讨长海医院消化内镜中心10年胃溃疡及十二指肠球部溃疡的内镜检出率是否有随季节变化的规律、上消化道内镜操作例数的变化趋势，以及不同性别、年龄及就诊状态患者的消化性溃疡检出率是否不同。方法根据2004年至2014年中国农历节气变化规律，划分不同季节的时间段，并将内镜数据归类。不同性别、年龄组及就诊状态患者消化性溃疡检出率等计数资料行X。检验。以One—Way-ANOVA检测内镜操作例数及消化性溃疡检出例数是否有随时间增多或减少的趋势，并用二分类Logistic回归的方法检验胃溃疡及十二指肠球部溃疡的内镜检出率是否存在季节性差异。结果研究共导出了215692例内镜报告，其中33559例被诊断为消化性溃疡，胃溃疡18270例，十二指肠球部溃疡15289例。不同性别、年龄组、就诊状态、年度、季节的患者消化性溃疡检出率差异均有统计学意义。胃溃疡（P〈0．01，OR=0．983，95％CI：0．976～0．987）及十二指肠球部溃疡（P〈0．05，OR=0．992，95％CI：0．986—0．997）的检出率呈下降趋势。各季节上消化道操作例数差异无统计学意义，但胃溃疡内镜检出率（P〈0．01，OR=1．04，95％CI：1．03—1．06）及十二指肠球部溃疡内镜检出率（P〈0．01，OR=1．05，95％CI：1．03～1．06）均有随季节变化的规律。冬季胃溃疡和十二指肠球部溃疡检出率均最高，分别为9．26％和8．38％，胃溃疡春季检出率较低（8．16％），十二指肠球部溃疡秋季检出率最低（5．88％）。结论在2004年1月至2014年2月期间，内镜实施例数显著提升，并显示了一定的季节性变化规律。虽然胃溃疡和十二指肠球部溃疡的检出例数提升，但其检出率却显著下降。两种消化性溃疡都有显著的季节性变化规律，均表现为冬季检出率最高。Objective To detect the changing discipline of detection rate of gastric and duodenal ulcers varied by season based on the database of Digestive Endoscopy Center of Changhai Hospital of l0 years and the trend of the number of upper endoscopies in Changhai Hospital, and to figure out the detection rate of peptic ulcer in different genders, age groups and patient status. Methods All endoscopy data were listed by season. The number of endoscopic procedures and diagnosis were obtained. The analysis of detection rate of peptic ulcer disease in different seasons in different gender, age group and patient status was conducted using the chi square test. One-Way-ANOVA test was used to validate the time trends of the number of endoscopic procedures and diagnosis, while binary logistic regression was used for detection rate of peptic ulcer disease. Results A total of 215 692 endoscopic reports were derived from the database, among which 33 559 were diagnosed as peptic ulcer, with 18 270 as gastric ulcer and 15 289 as duodenal ulcer. There were significant differences in detection rates of peptic ulcer disease in different seasons in different gender, age group and patient status. The detection rates of gastric ulcer （P〈0. 01, OR = 0. 985, 95% （3： 0. 976-0. 987） and duode- nal ulcer （P〈0. 05, OR=O. 992, 95%CI：0. 986-0. 997） decreased along the time trend. The detection rates of gastric ulcer （P〈0. 01, OR= 1.04, 95%C1： 1.03-1.06） and duodenal ulcer（P〈0. 01, OR=- 1.05, 95% CI： 1.03-1.06） showed a significant seasonal variation. The detection rate of gastric ulcer was higher in winter （9.26%） and lower in spring （8. 16%）. As for duodenal ulcer, the detection rate is also higher in winter （8.38%） , but lower in autumn （5.88%）. Conclusion From 2004 January to 2014 February, the number of endoscopic procedures increased and showed a significant seasonal variation. Although the number of endoscopic diagnosis increased in the past 10 years, the overall detection rate of the two kinds

关 键 词：消化性溃疡 上消化道内镜 季节 

分 类 号：R573.1[医药卫生—消化系统]