血液白细胞分析在青中年精神分裂症患者中的临床意义  

Clinical significance of white blood cells from blood in young and middleaged patients with schizophrenia

作　　者：律东[1] 冼君定 谢博 温金峰 尹玲[5] 陈铭扬 殷静雯[1] 林举达[1] 

机构地区：[1]广东医学院附属医院精神心理科,广东湛江524001 [2]广东医学院人文与管理学院暨生命质量与应用心理研究中心,广东东莞523808 [3]深圳市南山区慢性病防治院,深圳518000 [4]广东三九脑科医院心理科,广州510510 [5]广东省江门市第三人民医院心理科,广东江门529000

出　　处：《中国当代医药》2016年第12期39-41,共3页China Modern Medicine

摘　　要：目的分析血液白细胞在青中年精神分裂症患者中的临床意义,为隐性细菌性感染作为精神分裂症的始发原因寻找依据。方法选取2006年1月~2014年12月我院精神心理科住院的精神分裂症患者为病例组,并随机抽取体检中心体检的健康体检人群为对照组进行1∶1匹配的病例对照研究,应用统计描述、t检验、单因素条件性Logistic回归对数据进行统计分析。结果病例组和对照组分别收集了247例,病例组白细胞计数、中性粒细胞计数均高于对照组,差异有统计学意义（P〈0.05）;单因素条件性Logistic回归显示白细胞计数（OR=1.135,95%CI 1.035~1.245）、中性粒细胞（OR=1.197,95%CI 1.074~1.443）、中性粒细胞百分比（OR=4.653,95%CI 2.189~9.893）均是精神分裂症的高危因素。结论精神分裂症患者血液中白细胞水平较对照组高,血液白细胞水平增高是精神分裂症的高危因素,提示精神分裂症患者存在隐性细菌性感染的可能。Objective To analyze the clinical significance of white blood cells from blood in young and middle-aged patients with schizophrenia,and look for the basis of recessive bacterial infections as an originatingreason of schizophrenia. Methods From January 2006 to December 2014,schizophrenic patients hospitalized in psychological department in our hospital were selected as case group,and cases of healthy people for physical examinations were randomly selected from physical examination center and classified into control group.The case control study in one to one matching was carried out,and these data were statistically analyzed by statistical description,t test,and univariate conditional Logistic regression. Results There were 247 cases collected in each case group and control group.In the case group,white blood cell count,and neutrophil count was higher than that in the control group respectively,with statistical differences（P 0.05）.Univariate conditional Logistic regression were displayed that white blood cell count（OR =1.135,95% CI 1.035-1.245）,neutropenia（OR=1.197,95%CI 1.074-1.443）,and neutrophilic granulocyte percentage（OR=4.653,95%CI 2.189-9.893） were all high-risk factors of schizophrenia. Conclusion The white blood cell count from blood is higher than that in the healthy control group in schizophrenic patients.Increase of white blood cell is a high-risk factor of schizophrenia,which indicates the possibility of recessive bacterial infection in schizophrenic patients.

关 键 词：精神分裂症 隐性感染 白细胞 中性粒细胞 

分 类 号：R749.3[医药卫生—神经病学与精神病学]