动脉灌注化疗联合^(125)I粒子植入治疗非小细胞肺癌的临床研究  

Clinical Study on Artieral Infusion Chemotherapy Combined with ^(125)I Seed Implantation in Treatment of NSCLC

作　　者：任伟超[1] 孙成建[1] 王彦华[1] 刘彤晖[1] 赵晓龙[1] 王洪雨[1] 

机构地区：[1]青岛大学附属医院介入医学科,山东青岛266003

出　　处：《中国呼吸与危重监护杂志》2016年第3期256-260,共5页Chinese Journal of Respiratory and Critical Care Medicine

摘　　要：目的探讨动脉灌注化疗联合^(125)I粒子植入治疗非小细胞肺癌(NSCLC)的临床疗效与安全性。方法纳入2012年2月至2013年6月我科收治的无法手术切除的NSCLC患者34例,其中18例患者单纯接受了^(125)I粒子植入治疗,16例给予联合动脉灌注化疗。对所有患者进行随访,在^(125)I粒子植入术后2个月复查胸部CT,按实体瘤疗效评价标准评价治疗效果并进行生存分析。结果患者手术成功率为100%,未出现严重并发症。2个月后复查结果显示:单纯粒子植入组有效率为72.2%,联合动脉灌注化疗组有效率为87.5%,两组治疗的有效率差异无统计学意义(χ2=1.122,P>0.05),中位生存时间分别是361 d和470 d,两组差异有统计学意义(χ2=2.985,P<0.05),1年生存率分别为43.5%和83.5%,两组差异有统计学意义(χ2=4.101,P<0.05)。结论动脉灌注化疗联合^(125)I粒子植入治疗不可切除的NSCLC安全可靠、疗效肯定,能延长患者生存期。Objective To evaluate the clinical efficacy and safety of artieral infusion chemotherapy combined with^（125） I seed implantation in treatment of non-small cell lung cancer（ NSCLC）. Methods Between February 2012 to June 2014,34 patients with unresectable NSCLC received^（125） I seed implantation,in which 16 patients also received artieral infusion chemotherapy. All the patients were followed up and two months after^（125） I seed implantation the thoracic CT scanning was carried out in all patients. The response to treatment was evaluated in accordance with Response Evaluation Criteria in Solid Tumors and the accumulated survival rate was analyzed by means of Kaplan-Meier. Results The operation successful rate was 100% and no severe complications were observed. Two months later the thoracic CT scanning showed that patients who only received^（125） I seed implantation with a total effective rate of 72. 2% and those received artieral infusion chemotherapy combined with^（125） I seed implantation with an effective rate of 87. 5%,with no significant difference between two groups in the effective rate（ χ2= 1. 122,P〉 0. 05）. Median survival time of two groups was 361 days and 470 days（ χ2= 2. 985,P〈 0. 05）,respectively. Survival rate of 1 year was43. 5% and 83. 5%（ χ2= 4. 101,P〈 0. 05）,respectively. Conclusion Artieral infusion chemotherapy combined with^（125） I seed implantation is safe,reliable and effective in treatment of unresectable NSCLC,which can prolong the patient＇s survival time.

关 键 词：非小细胞肺癌 125I粒子植入 动脉灌注 化疗 

分 类 号：R734.2[医药卫生—肿瘤]