鼻腔软骨-骨呼吸上皮性腺瘤样错构瘤临床病理观察  

Chondro-osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity

作　　者：徐仟[1] 刘红刚[1] 朴颖实[1] 王成硕[2] 董格红[1] 何春燕[1] 

机构地区：[1]首都医科大学附属北京同仁医院病理科,北京100730 [2]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730

出　　处：《诊断病理学杂志》2016年第5期353-356,共4页Chinese Journal of Diagnostic Pathology

基　　金：头颈部分子病理诊断北京市重点实验室科题

摘　　要：目的探讨鼻腔软骨-骨呼吸上皮性腺瘤样错构瘤(COREAH)临床病理特点。方法报道1例鼻腔软骨-骨呼吸上皮性腺瘤样错构瘤,回顾分析其临床、影像学、病理组织学特点,探讨其诊断及鉴别诊断。结果患儿3岁,男性,鼻塞伴脓涕6个月。鼻腔镜检查示左侧鼻腔粉红色新生物,堵满整个左鼻道。MRI示左鼻腔后筛和嗅裂来源肿物,未见骨质破坏。组织学表现为息肉样病变,纤维黏液样间质,被覆假复层纤毛柱状上皮,上皮下见增生的呼吸上皮性腺体,囊性扩张,周围见散在软骨岛。间质内少量淋巴浆细胞浸润。结论 COREAH是一种少见的鼻腔错构瘤,常见于儿童。大体表现为息肉样病变,组织病理诊断关键在于同时具有呼吸上皮性腺体和软骨或骨成分。Objective To study the clinical and pathological characteristics of nasal chondro-osseous respiratory epithelial adenomatoid hamartoma（ COREAH）. Methods One case of COREAH was presented and the relevant clinical data,radiologic findings and pathological characteristics were reviewed. The diagnosis and differential diagnosis were also described. Results A 3-year-old boy presented as nasal obstruction with purulent nose for 6 months. Nasal endoscopy revealed a pink mass occupying the left nasal cavity. MRI showed a mass located in left poster ethmoid sinus and olfactory groove of the left nasal cavity without bone destruction. Histologic examination showed polypoid lesion that was lined by pseudostratified ciliated columnar epithelium. The lesion contained a fibromyxoid stroma,in which proliferated respiratory glands were present,some of which were cystically dilated. Sporadic islands of cartilage also existed. A few lymphocytes and plasma cells were infiltrated in the stroma. Conclusion COREAH is a rare nasal hamartoma and more common in children. Grossly,COREAH tends to have a polypoid appearance. The key points of its histopathologic diagosis are both respiratory epithelium glands and cartilage / bone.

关 键 词：鼻腔 错构瘤 病理学 

分 类 号：R739.62[医药卫生—肿瘤]