子宫内膜小细胞神经内分泌癌临床病理观察  

Small cell neuroendocrine carcinoma of the endometrium:a case report and review of literature

作　　者：程静[1] 涂频[2] 王建军[2] 何燕[2] 周晓军[2] 石群立[2] 

机构地区：[1]无锡市妇幼保健院病理科 [2]南京军区南京总医院病理科,南京210002

出　　处：《诊断病理学杂志》2016年第5期361-364,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨子宫内膜小细胞神经内分泌癌(SCNEC)临床病理特点、预后与治疗。方法总结1例子宫内膜小细胞神经内分泌癌的临床表现、病理形态及免疫组化特点,并复习相关文献。结果患者女性,61岁。绝经后阴道排液及出血。术前诊断性刮宫,病理诊断为小细胞神经内分泌癌,行广泛性全子宫、双附件切除和盆腔淋巴结清扫术。临床病理分期为子宫内膜小细胞神经内分泌癌Ⅰb期。免疫组化:CgA、Syn和CD56(+)。患者术后行化疗,已无瘤生存8个月。结论原发性子宫内膜小细胞神经内分泌癌罕见,具有较强侵袭性,预后差,手术、放疗及化疗等综合治疗可能改善预后。Objective To investigate clinicopathological features,prognosis and treatment of small cell neuroendocrine carcinoma of the endometrium. Methods We reported one case of this rare tumor and reviewed the literature. Results A 61-year-old female presented with abnormal vaginal discharge and bleeding. She underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy and radical pelvic lymph node resection. The case were stage Ⅰb according to postoperative pathology. Pathological examination revealed small cell neuroendocrine carcinoma of endometrium. Immunohistochemical evidence of neuroendocrine differentiation was demonstrated by using markers such as synaptophysin,CD56 and chromogranin A. She recieved chemotherapy and was alive with no evidence of disease for eight month. Conclusion Primary small cell neuroendocrine carcinoma of the endometrium is extremely rare and aggressive disease. Although the prognosis of small cell neuroendocrine carcinoma of endometrium is poor,surgery combined with chemotherapy and radiotherapy may contribute to an improved prognosis.

关 键 词：小细胞癌 子宫内膜 临床病理 免疫组化 预后 

分 类 号：R737.33[医药卫生—肿瘤]