槐耳颗粒治疗原发性支气管肺癌的临床疗效  

Huaier Granlule on Primary Bronchogenic Carcinoma

作　　者：高平[1] 陆依珊 吴兰[3] 栾月 丁苗苗[3] 张小丹[3] 梁洪禄 

机构地区：[1]大连医科大学附属第一医院,辽宁大连116000 [2]大连市8中,辽宁大连116000 [3]大连医科大学,辽宁大连116000

出　　处：《辽宁中医杂志》2016年第5期994-997,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:研究应用槐耳颗粒治疗原发性支气管肺癌的临床疗效。方法:以大连医科大学附属第一医院2013年1月—2015年12月因诊断为非小细胞肺癌(NSCLC)住院的病例84例,随机分为化疗组和观察组(槐耳颗粒联合化疗),每组42例,分析比较两组患者临床疗效,生活质量,免疫功能、不良反应等指标变化。结果:观察组有效率及病灶稳定率均高于化疗组,但差异均无统计学意义。生活质量(KPS评分)改善情况观察组优于化疗组(P<0.05)。观察组临床症状总改善率(显著改善+部分改善)优于化疗组(P<0.05),且两组治疗前后在咳嗽、胸痛、潮热等症状方面的改善情况观察组优于化疗组(P<0.05)。治疗后观察组和化疗组CD3、CD4及NK细胞比例差异具有统计学意义(P<0.05),而CD8细胞比例差异无统计学意义。化疗组和观察组治疗后肿瘤标志物CEA、CA19-9降低率比较均具有统计学意义。两组不良反应发生方面的差异均无统计学意义。结论:槐耳颗粒可改善NSCLC患者主要临床症状,提高其生活质量,增强细胞免疫功能,对NSCLC患者具有重要的辅助治疗作用。Objective： To explore the effect of Huaier Granule on treatment of primary bronchogenic carcinoma. Methods： Eighty- four cases with non- small cell lung cancer（ NSCLC） were collected. In the first Affiliated Hospital of Dalian Medical University from January 2013 to December 2015,all cases were randomly divided into chemotherapy group and observation group（ Huaier Granule in combination with chemotherapy）. Analyze the clinical efficacy,quality of life,immune function and other side effects between two groups. Results： The effective rate and stable lesions rate of observation group were higher than those of the chemotherapy group but the differences were not statistically significant. Improvement of quality of life（ KPS score） in the observation group was better than the chemotherapy group＇s（ P 0. 05）. Overall improvement rate of clinical symptoms in the observation group（ significant improvement ＋ partial improvement） was better than that of the chemotherapy group（ P 0. 05） and before and after treatment,improvement of cough,chest pain,hot flashes in the observation group were better than those of the chemotherapy group（ P 0. 05）. After treatment,differences of CD3,CD4 and NK cells proportion in the observation group and the chemotherapy group were statistically significant（ P 0. 05） while the proportion of CD8 cells had no significant difference. The differences of tumor markers CEA and CA19- 9 were statistically significant between chemotherapy group and observation group.The adverse events between the two groups were not statistically significant. Conclusion： Huaier Granule could improve clinical symptoms in patients with NSCLC,improve their quality of life,enhance immune function and has an important role of adjuvant therapy for NSCLC patients.

关 键 词：槐耳颗粒 肺癌 疗效 临床研究 

分 类 号：R734.2[医药卫生—肿瘤]