37例青少年HIV/AIDS病人抗病毒治疗疗效观察  

Short-term effect observation of antiretroviral therapy in 37 adolescent HIV/AIDS cases

作　　者：李建维[1] 邵英[1] 马红丽[1] 叶江竹[1] 贺亮[1] 林燕会[1] 刘安[1] 孙丽君[1] 

机构地区：[1]首都医科大学附属北京佑安医院,北京100069

出　　处：《中国艾滋病性病》2016年第5期315-316,共2页Chinese Journal of Aids & STD

摘　　要：目的了解青少年艾滋病抗病毒治疗的基本特点,为艾滋病防控和综合治疗提供科学依据。方法采集2002年1月-2015年1月(AIDS)在北京佑安医院接受抗病毒治疗的青少年艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人的临床资料,分析和探讨青少年抗病毒治疗的特点。结果收录的37例HIV感染者/AIDS病人中,性传播占91.89%。基线时HIV-1病毒载量为(4.40±4.83)Log拷贝/mL,抗病毒治疗5年后,病毒载量降至(0.87±0.82)Log拷贝/mL,差异有统计学意义(t=3.149,P=0.003)。病毒载量完全抑制者所占的比例由0增加至94.7%(P<0.001);抗病毒治疗5年时CD4+T淋巴细胞计数由基线的(179±102)个/μL升高至(732±136)个/μL,治疗前后比较差异有统计学意义(t=17.118,P<0.001)。结论抗病毒治疗可有效抑制青少年HIV感染者/AIDS病人的病毒载量,改善其免疫功能,应推广HIV感染青少年的抗病毒治疗,加强艾滋病宣传教育,以控制HIV在青少年人群的传播。Objective To understand the basic characteristics of adolescent HIV antiretroviral therapy（ART）and provide a scientific basis for AIDS prevention and comprehensive treatment.Methods Clinical data were collected in adolescent HIV/AIDS cases receiving ART from January 2002 to January 2015 in our hospital,and the characteristics of adolescents HIV ARTwereanalyzed and explored.Results Of the 37 adolescent HIV/AIDS cases,91.89% were sexually transmitted.After5year-ART,their HIV viral load significantly decreased from（4.40 ±4.83）log copies/mL at baseline to（0.87±0.82）log copies/mL（t=3.149,P=0.003）.Percentage of complete viral suppression significantly increased from 0% at baseline to 94.7%（P〈0.001）.CD4 cells increased from 179 ±102cells/μL at baselineto 732 ± 136cells/μL.The difference was statistically significant（t=17.118,P〈0.001）.Conclusion ARTcan effectively suppress viral load and improve immune function in adolescent HIV/AIDS patients.ART should be promotedamongadolescent HIV/AIDS patients and AIDS education should be strengthened to control HIV spreadamong adolescent population.

关 键 词：艾滋病 青少年 抗病毒治疗 疗效观察 

分 类 号：R512.91[医药卫生—内科学]