肌萎缩侧索硬化患者重复神经电刺激变化与疾病进展的相关性  

The correlation of disease progression rate and repetitive nerve stimulation in patients with amyotrophic lateral sclerosis

作　　者：张洁 崔丽英[2] 

机构地区：[1]航空总医院神经内科,100023 [2]中国医学科学院北京协和医学院北京协和医院神经内科,100073

出　　处：《中国神经免疫学和神经病学杂志》2016年第3期182-184,共3页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的探讨肌萎缩侧索硬化(ALS)患者重复神经电刺激(RNS)变化与疾病进展的关系。方法收集2008-05—2009-04北京协和医院神经科门诊或病房确诊或拟诊的ALS患者101例,均行常规神经传导速度(NCV)和RNS检查,并进行ALS-FRS评分,评估疾病进展速度及神经电生理指数(NI)。结果 RNS阳性ALS患者NI指数低于RNS阴性组(2.14±1.55比2.82±1.66,P<0.05);RNS阳性组与RNS阴性组病情进展速度中位数(四分位数间距)分别为0.86(0.86)和0.50(0.66),RNS阳性组疾病进展速度较RNS阴性组增加(P<0.05)。结论 ALS患者RNS阳性是疾病活跃的表现,患者病情进展速度快;RNS检查有利于对患者预后做出判断。Objective To investigate the relationship between the changes of repetitive nerve stimulation（RNS）and the speed of disease progression in patients with amyotrophic lateral sclerosis（ALS）.MethodsFrom May 2008 to April 2009,101 patients with ALS who were diagnosed or suspected to be diagnosed in a neurological clinic or ward were tested with routine nerve conduction（NCV）and RNS,and the ALS-FRS score was assessed.The speed of disease progression and neurophysiological index（NI）were evaluated.Results NI index in the RNS positive group（2.14±1.55）was lower than that in the RNS negative group（2.82±1.66,P〈0.05）.The median rate of disease progression（the interquartile range）in RNS positive group [0.86（0.86）]was significantly higher than that in the RNS negative group [0.50（0.66）,P〈0.05].ConclusionsRNS positive indicates that the disease is active in ALS patients,and the progression of the disease is significantly accelerated.RNS examination of patients with ALS has important guiding significance on prognosis.

关 键 词：肌萎缩侧索硬化 重复电刺激 疾病进展速度 

分 类 号：R746.4[医药卫生—神经病学与精神病学]