多种方法联合干预预防妊娠期高血压疾病的临床分析  

Clinical analysis of multiple methods combined to prevent hypertensive disorder complicating pregnancy

作　　者：王晶[1] 东星[2] 吴鸿雁[1] 尚丽新[1] 

机构地区：[1]北京军区总医院妇产科,北京100700 [2]北京军区总医院普外科,北京100700

出　　处：《安徽医药》2016年第5期917-920,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨多种方法联合干预预防妊娠期高血压疾病的效果,为该病的预防提供新的可行性方法。方法选取孕妇共1 050例,分为3组。A组380例孕妇采用饮食管理,同时进行补锌、钙、叶酸、维生素B12等药物干预,B组350例孕妇进行适度锻炼、体质量管理等干预,C组320例孕妇进行常规孕产期宣教和产检,比较3组血清锌、钙、叶酸、维生素B12水平及妊娠合并症、并发症的发病率。结果 (1)A组孕妇的血钙、锌、叶酸、维生素B12水平均高于B组及C组(P<0.01),B组孕妇的血钙、锌水平高于C组(P<0.01)。(2)妊娠期高血压疾病、HELLP综合征、羊水过少的发生率A组及B组均明显低于C组,差异有统计学意义(均P<0.01);A组低于B组,但差异无统计学意义(P>0.05)。(3)A组孕妇的剖宫产、产后出血、早产、新生儿窒息发生率均明显低于C组(P<0.01);B组孕妇的剖宫产、产后出血发生率均明显低于C组(P<0.01)。结论孕期注重饮食调节,并进行补充钙、锌、叶酸、维生素B12及适度锻炼、体质量管理等联合干预,可以有效的降低妊娠期高血压疾病的发生率,改善妊娠结局。Objective To investigate the effect of combined treatment of various methods to prevent hypertensive disorder complicating pregnancy( HDCP),and to provide a new feasible method for the prevention of this disease. Methods Totally 1 050 cases of pregnant outpatients recorded in General Hospital of Beijing Military Command from January to December 2014 were randomized into 3 groups.Group A with 380 pregnant women underwent diet management,and were supplied with zinc,calcium,folic acid,vitamin B12. Group B with 350 pregnant women were given exercise regulation and weight management. Group C with 320 pregnant women had routine prenatal examination. The serum levels of zinc,calcium,folic acid,vitamin B12 and the incidence of pregnancy complications were compared among 3 groups. Results The calcium,zinc,folic acid and vitamin B12 levels in group A were significantly higher than those in group B and C( P < 0. 01),and the calcium and zinc levels of group B were higher than those of group C( P < 0. 01). The incidences of HDCP,HELLP syndrome and oligohydramnios in group A and B were significantly lower than those in group C( P < 0. 01). The incidences of cesarean section,postpartum hemorrhage,premature delivery,neonatal asphyxia were significantly lower in group A than those in group C( P < 0. 01); The incidences of cesarean section,postpartum hemorrhage in group B were significantly lower than those in group C( P< 0. 01). Conclusions Diet regulation combined with the intervention of calcium,zinc,folic acid,vitamin B12 and body weight management can effectively reduce the incidence of HDCP and improve pregnancy outcome.

关 键 词：高血压 妊娠性 营养政策 膳食 减重 妊娠结局 

分 类 号：R714.246[医药卫生—妇产科学]