抑炎性细胞因子在多发性硬化中的研究进展  

Advances of anti-inflammatory cytokines in multiple sclerosis

作　　者：汪丹[1] 王哲[1] 刘丽波[2] 李彧媛[3] 

机构地区：[1]大连医科大学附属第一医院神经内科,辽宁大连116011 [2]大连医科大学附属第一医院检验科,辽宁大连116011 [3]大连医科大学,辽宁大连116011

出　　处：《转化医学杂志》2016年第3期158-161,共4页Translational Medicine Journal

基　　金：国家自然科学基金青年基金(61302030)

摘　　要：多发性硬化是最常见的中枢神经系统炎性脱髓鞘性疾病,目前其病因及发病机制尚不明确,治疗手段也有限。抑炎性细胞因子通过参与免疫耐受性的产生,降低多发性硬化患者体内的炎性反应。合理地理解抑炎性细胞因子在多发性硬化中的免疫调节机制,将对多发性硬化发病机制及相关药物治疗的研究有重要价值。Multiple sclerosis is the most common inflammatory demyelinating disease of the central nervous system. At present, its etiology and pathogenesis are unclear, and its treatment is also limited. Anti-inflammatory cytokines are involved in the generation of immunotolerance, and can protect the host during immune responses. Rational understanding of the immunoregulatory mecha-nisms will have a considerable effect on pathogenesis and drug therapy for multiple sclerosis.

关 键 词：多发性硬化 抑炎性细胞因子 发病机制 药物治疗 

分 类 号：R744.51[医药卫生—神经病学与精神病学]