调控牙萌出的细胞及分子机制研究进展  

Research progress on the cellular and molecular mechanisms of tooth eruption

作　　者：黄诗言[1] 饶南荃[1] 徐舒豪 李小兵[1] 

机构地区：[1]口腔疾病研究国家重点实验室华西口腔医院儿童口腔科(四川大学),成都610041

出　　处：《华西口腔医学杂志》2016年第3期317-321,共5页West China Journal of Stomatology

摘　　要：牙萌出是指牙冠形成后向平面移动,穿过牙槽骨和口腔黏膜到达功能位置的一系列复杂生理过程。目前研究认为,牙萌出由牙槽骨、牙囊、破骨细胞、成骨细胞及多种细胞因子等共同调控,其中牙囊参与调控牙槽骨吸收与形成,是牙萌出的必要条件;同时,牙根形成及牙周韧带在牙齿持续萌出阶段发挥作用。牙萌出的具体调控机制尚不明确,本文就牙萌出过程中发挥调控作用的细胞及分子机制的研究现状作一综述。Tooth eruption is a series of complicated physiological processes occurring once the crown is formed completely, as well as when the tooth moves toward the occasion plane. As such, the tooth moves through the alveolar bone and the oral mucosa until it finally reaches its functional position. Most studies indicate that the process of tooth eruption involves the alveolar bone, dental follicles, osteoclasts, osteoblasts, and multiple cytokines. Dental follicles regulate both resorption and formation of the alveolar bone, which is required for tooth eruption. Furthermore, root formation with periodontal ligament facilitates continuous tooth eruption. However, the exact mechanism underlying tooth eruption remains unclear. Hence, this review describes the recent research progress on the cellular and molecular mechanisms of tooth eruption.

关 键 词：牙萌出 牙囊 牙槽骨 核因子ΚB受体活化因子 核因子ΚB受体活化因子配体 骨保护素 

分 类 号：R781[医药卫生—口腔医学]