视黄醇结合蛋白、转铁蛋白及胆碱酯酶在结直肠癌中的表达及临床意义  

Expression and clinical significance of retinol-binding protein, transferrin, and cholinesterase in colorectal cancer patients

作　　者：徐振宇[1] 李丁[2] 徐闻欢[1] 高翔[1] 茆勇[1] 华东[1] 

机构地区：[1]江南大学附属医院肿瘤中心无锡市第四人民医院肿瘤科,无锡214062 [2]南京医科大学附属无锡人民医院骨科,214023

出　　处：《中华实验外科杂志》2016年第5期1351-1353,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金（81372375、81201600）;江苏省自然科学基金（BK2012538）

摘　　要：目的 观察结直肠癌患者术前视黄醇结合蛋白（RBP）、转铁蛋白（TRF）和胆碱酯酶（CHE）水平对于肿瘤进展及预后的影响.方法 检测151例结直肠患者术前RBP、TRF和CHE水平,收集其临床病理资料,随访总生存期（OS）,并进行统计学分析.结果 RBP水平低龄组为（36.42±11.12） mg/L,明显高于高龄组的（28.38±13.61） mg/L（P＜0.01）;CHE水平在原发结肠者为（6 545.95±2 315.54） U/L,明显低于原发直肠者的（7525.78±2407.31） U/L（P ＜0.05）.术前RBP水平与结直肠癌浸润深度、淋巴结转移数目、出现远处转移及TNM分期均明显相关（P＜0.05）;术前CHE水平与结直肠癌浸润深度及TNM分期均明显相关（P＜0.05）;术前TRF水平与结直肠癌浸润深度、淋巴结转移数目及远处转移明显相关（P＜0.05）.CHE高水平组的OS为50.7个月,明显高于CHE低水平组的40.4个月（P＜0.05）;RBP高水平组的OS为55.2个月,明显高于RBP低水平组的34.9个月（P＜0.01）;TRF低水平组的OS有低于高水平组的趋势,但差异无统计学意义（P＞0.05）.结论 术前TRF水平可作为结直肠癌进展较为有价值的指标,RBP、CHE对结直肠癌进展和预后均有参考价值.Objective To observe the effects of retinol-binding protein （RBP）,transferrin （TRF）,and cholinesterase （CHE） on progression and prognosis of colorectal cancer.Methods The serum RBP,TRF,and CHE in 151 patients with colorectal cancer were detected,and the overall survival of all patients was followed up.Results The RBP level in younger individuals with colorectal cancer was （36.42 ± 11.12） mg/L,significantly higher than in older individuals [（28.38 ± 13.61） mg/L] （P 〈 0.01）.CHE level in colon cancer was （6 545.95 ± 2 315.54） U/L,significantly lower than in rectal cancer [（7 525.78 ± 2 407.31） U/L] （P 〈 0.05）.Decreased RBP levels were associated with deeper invasion,more metastatic lymph nodes,distant metastasis and later TNM stage （P 〈 0.05）;Decreased TRF levels were associated with deeper invasion,more metastatic lymph nodes,and distant metastasis （P 〈 0.05）.The overall survival of patients with higher CHE levels was significantly longer than in those with lower CHE levels （50.7 months vs.40.4 months,P 〈0.05）.The overall survival of patients with higher RBP levels was significantly longer than in those with lower RBP levels （55.2 months vs.34.9 months,P 〈 0.01）.There was no statistically significant difference between higher and lower TRF levels （P 〉 0.05）.Conclusion Serum TRF level was valuable prediction of progression of colorectal caner,and RBP and CHE were potential factors for both prediction of progression and prognosis.

关 键 词：视黄醇结合蛋白 转铁蛋白 胆碱酯酶 结直肠癌 

分 类 号：R735.34[医药卫生—肿瘤]