银杏达莫注射液对自发性腹膜炎患者血清和腹水可溶性髓样细胞触发受体-1及血浆D-二聚体的影响  

Effect of Ginkgo leaf extract and dipyridamole injection on serum and ascetic fluid levels of soluble triggering receptor expressed on myeloid cells-1 and plasma D-dimer in patients with spontaneous bacterial peritonitis

作　　者：张晓苹[1] 赵宏军[2] 马阿火[1] 秦月花[1] 孙爱静[3] 王晓丽[1] 王兴木[3] 

机构地区：[1]浙江省绍兴市人民医院浙江大学绍兴医院消化内科,绍兴312000 [2]浙江省绍兴市人民医院浙江大学绍兴医院神经内科,绍兴312000 [3]浙江省绍兴市人民医院浙江大学绍兴医院中心实验室,绍兴312000

出　　处：《中华实验外科杂志》2016年第5期1363-1365,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 探讨银杏达莫注射液对自发性腹膜炎（SBP）腹水患者血清和腹水中可溶性髓样细胞触发受体-1（sTREM-1）及D-二聚体的影响及临床疗效.方法 肝硬化腹水并发SBP患者48例随机分为治疗组23例和对照组25例.两组患者均以低盐饮食及常规治疗.治疗组加用银杏达莫注射液25 ml每日1次,连续2周.观察两组患者治疗前后血清和腹水中sTREM-1及D-二聚体的变化,比较两组临床疗效和药品不良反应发生.结果 两组患者治疗后血清sTREM-1、腹水sTREM-1及D-二聚体水平均较治疗前明显下降[血清sTREM-1：（217.28 ±87.65） pg/ml比（52.02±16.36） pg/ml;腹水sTREM-1：（218.76±69.38） pg/ml比（74.07±25.81）pg/ml;D-二聚体：（3.87±2.08） mg/L比（0.45±0.43） mg/L;P＜0.01].治疗组总有效率为69.6％,对照组有效率为60.0％（P＞0.05）.两组患者治疗期间未见明显药品不良反应.结论 银杏达莫注射液能降低SBP患者sTREM-1及D-二聚体水平,提高治疗有效率.Objective To explore the effect of Ginkgo leaf extract and dipyridamole injection on serum and ascetic fluid levels of soluble triggering receptor expressed on myeloid cells-1 （sTREM-1） and plasma D-dimer in patients with spontaneous bacterial peritonitis （SBP）.Methods Totally 48 cirrhosis patients with SBP were randomly divided into therapeutic group （23 cases） and control group （25 cases）.All the patients were given the standard treatment and low-salt diet.The patients in therapeutic group were treated with Ginkgo leaf extract and dipyridamole injection 25 ml,once every day for 2 weeks.The serum and ascetic fluid levels of sTREM-1 and plasma D-dimer were measured pre-and post-therapy,and clinical effects and side effects were observed.Results In the two groups,the levels of serum and ascetic fluid sTREM-1 and plasma D-dimer were decreased significantly post-therapy as compared with those pre-therapy [serum sTREM-1：（217.28 ± 87.65） pg/ml vs.（52.02 ± 16.36） pg/ml;ascetic sTREM-1：（218.76 ± 69.38） pg/ml vs.（74.07 ± 25.81） pg/ml;P 〈 0.01,respectively];D-dimer：[（3.87 ±2.08） mg/L vs.（0.45 ±0.43） ng/L;P 〈0.01].The total effective rate in therapeutic group and control group was 69.6% and 60.0% respectively （P 〉 0.05）.There was no obvious adverse drug reaction observed during the treatment in the two groups.Conclusion Ginkgo leaf extract and dipyridamole injection can down-regulate the serum and ascetic fluid levels of sTREM-1 and plasma D-dimer,relieve the local inflammatory reaction,and improve the response rate.

关 键 词：自发性细菌性腹膜炎 肝硬化 银杏达莫注射液 可溶性髓样细胞触发受体-1 D-二聚体 

分 类 号：R572.2[医药卫生—消化系统]