雌激素受体β可能为女性非小细胞肺癌性激素依赖性患者的筛选因素  

Estrogen receptor β may be factor screening for sex hormone dependence of female patients with non-small lung cancer

作　　者：卢珠明[1] 王正[2] 伍硕允[3] 李民[3] 叶敏[3] 林志潮[3] 沈涛[3] 

机构地区：[1]暨南大学第一临床医学院胸外科,广州510630 [2]暨南大学第二临床医学院胸外科,深圳518020 [3]广东省江门市中心医院中山大学附属江门医院胸外科,江门529030

出　　处：《中华实验外科杂志》2016年第5期1384-1386,共3页Chinese Journal of Experimental Surgery

基　　金：广东省科技计划项目（2012B061700064）;江门市科技计划项目（2012-58）

摘　　要：目的 检测女性非小细胞肺癌（NSCLC）患者雌激素受体（ER）表达,探讨其与临床病理特征及术后生存率的关系,筛选女性NSCLC性激素依赖性患者的可能因素.方法 应用免疫组织化学法检测125例女性NSCLC患者肿瘤标本中ERα和ERβ表达,分析其影响因素.Kaplan-Meier生存曲线比较生存率.结果 125例NSCLC患者ERα阳性0例,所有肺癌肿瘤细胞未发现ERα阳性.125例NSCLC患者ERβ阳性58例,阳性率为46.4％.ERβ阳性表达与年龄大小、绝经前后状态、肺癌的病理类型、分期明显相关,其中腺癌的阳性率最高,鳞癌的阳性率最低.随着分期增高,ERβ阳性表达也增高（P＜0.05）.ERβ阳性表达与肿瘤大小、分化程度、有无吸烟史不相关（P＞0.05）.绝经前ERβ阴性女性NSCLC患者生存率明显高于绝经前ERβ阳性患者（P＜0.05）;绝经后ERβ阳性女性NSCLC患者生存率明显高于绝经后ERβ阴性患者（P＜0.05）.结论 肺癌组织雌激素受体ERβ水平可以影响女性NSCLC生长和术后生存,可能是女性性激素依赖NSCLC筛选的1个重要因素.Objective To evaluate estrogen receptor （ER） expression and the relation-ship with clinicopathologic features and postoperative survival rate of female patients with non-small lung cancer （NSCLC）,screening for factor of sex hormone dependence in female patients.Methods 125 female patients undergoing surgical treatment for NSCLC were prospectively investigate for estrogen receptor Erα and Erβ expression by using immunohistochemistry.The influence factors were analyzed.Kaplan-Meier method was used for survival analysis.Results None expression of Erα were detected in 125 female patients with NSCLC.Positive expression Erβ was present in 58 patients （46.4%）,there was association between Erβ positivity with age,menopausal status,tumor types and tumor stage.No relationships were found between Erβ and tumor size,histologic differentiation as well as smoking situation.Adenocarcinomas were more likely to have Erβ positive tumors than squamous cell carcinoma and other types.there was a trend for a higher frequency with Erβ positive tumors and higher tumor staging.Premenopausal women with Erβ negative tumors demonstrated better survival compared with women with Erβ positive tumor,while promenopausal women with Erβ positive tumors demonstrated better survival compared with women with Erβ negative tumor （P 〈 0.05）.Conclusion The level of estrogen receptor Erβ may affect the tumor growth and postoperative survival of female patients,Erβ may be factors screening for sex hormone dependence of female patients with NSCLC.

关 键 词：非小细胞肺癌 女性 雌激素受体 

分 类 号：R734.2[医药卫生—肿瘤]