直肠癌术后患者血浆MMP-3水平变化观察  

Observation of variation of MMP-3 levels in plasma during perioperative period of patients with rectal cancer

作　　者：张中德 李辉[1] 智会[1] 

机构地区：[1]周口市中心医院,河南周口466000

出　　处：《中国民康医学》2016年第9期48-49,63,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察直肠癌患者术后1月内血浆MMP-3水平变化情况。方法:选取直肠癌根治术的患者146例,分别在术前1 d、术后第1、3、7、14、21、28天采集静脉血,使用ELISA法检测血浆MMP-3水平并进行比较分析。结果:术前1 d,患者的血浆MMP-3水平为(15.6±7.9)ng/ml(n=146),术后第1天(21.9±14.8 ng/ml,P<0.0001)、第3天(38.9±21.4 ng/ml,P<0.0001)、第7天(25.2±14.1 ng/ml,P<0.0001)、第14天(24.6±11.3 ng/ml,P<0.0001)、第21天(20.4±10.9 ng/ml,P=0.002)MMP-3水平较术前均有明显升高,直到第28天(16.3±7.7 ng/ml,P=0.07)才基本降到术前水平。结论:直肠癌患者术后3周内血浆MMP-3水平较术前明显升高。Objective:To observe variation of MMP-3 levels in plasma during the first month after radical surgery for rectal cancer. Methods:146 patients undergoing radical surgery for rectal carcinoma were involved in this study. Blood plasma samples had been collected 1 day before the operation and postoperative day 1,3,7,14,21 and 28. MMP-3 levels were analyzed via ELISA. Re-sults:The mean preoperative MMP-3 level was 15. 6±7. 9ng / ml(n=146). Significantly elevated mean plasma levels were noted on postoperative day 1(21. 9±14. 8 ng / ml,n=146,P<0. 0001),3(38. 9±21. 4 ng / ml,n=146,P<0. 0001),7(25. 2±14. 1 ng /ml,n=146,P<0. 0001),14(24. 6±11. 3 ng / ml,n = 137,P<0. 0001),and on 21(20. 4±10. 9 ng / ml,n = 129,P = 0. 002) when compared to preoperative levels. The plasma levels returned to the preoperative baseline at the postoperative day 28(16. 3±7. 7 ng / ml,n=126,P=0. 07). Conclusions:The plasma MMP-3 levels remains significantly elevated from baseline to 3 weeks after radical surgery.

关 键 词：直肠癌 MMP-3 直肠癌根治术 

分 类 号：R735.37[医药卫生—肿瘤]